T-cell acute lymphoblastic leukemia is an aggressive hematologic malignancy which is usuallyassociated with unfavorable prognosis particularly in patients with refractory/relapsed disease.Therefore, development of novel therapeutic strategies is highly required for improving theoutcome of these patients. Although there are several studies evaluating the efficacy of proteasome<...

The body's early defence in response to trauma, inflammation or infection, the acute phase response, is a complex set of systemic reactions seen shortly after exposure to a triggering event. One of the many components is an acute phase protein response in which increased hepatic synthesis leads to increased serum concentration of positive acute phase proteins. The serum concentration of these a...

Acute phase proteins have been studied widely in human medicine, especially as biomarkers of diseases, inflammatory processes and various infections, to diagnose and monitor the success of diseases, as well as to follow-up the treatment in clinical praxis (Hilliquin, 1995; Deans & Wigmore, 2005; Endre & Westhuyzen, 2008). However, the possible influence of inflammatory conditions on the concent...

Acute phase reaction is a systemic response which usually follows a physiological condition that takes place in the beginning of an inflammatory process. This physiological change usually lasts 1-2 days. However, the systemic acute phase response usually lasts longer. The aim of this systemic response is to restore homeostasis. These events are accompanied by upregulation of some proteins (posi...

The acute-phase proteins serum amyloid A protein (SAA) and secretory phospholipase A2 (sPLA2) are simultaneously expressed during inflammatory conditions. SAA associates with high-density lipoprotein (HDL) altering its physicochemical composition. We found that purified acute-phase SAA, but not the constitutive form, markedly enhances the lipolytic activity of sPLA2 in a dose-related manner wit...

Background. In order to minimize overtraining, a reliable method is required to analyze training loads. Objectives. The objective of this study was to see if session Rate of Perceived Exertion (sRPE) is a valuable tool for tracking changes in perceived training load and strain among Malaysia rugby 15-a-side players during preparation for a significant game. Methods. Twenty-eight (n=28) elite ...

The production of a systemic inflammatory response to intradermal monosodium urate crystal injection is described. A transient, self-limiting local response is associated with a systemic response detectable by a rise in the white cell count and serum amyloid A protein. The white cell change parallels the evolution of the local response, whereas the serum amyloid A response lags behind the local...

PURPOSE OF REVIEW Sepsis elicits profound changes in the concentrations of plasma proteins synthesized by liver parenchymal cells referred to as acute-phase proteins. Mechanisms controlling this orchestrated response include release of cytokines that induce acute-phase proteins, while other 'house-keeping' genes are downregulated. RECENT FINDINGS Although some acute-phase proteins help to con...

BACKGROUND Stroke is an important health problem that imposes socioeconomic burdens. OBJECTIVE To explore provider costs and to examine predictive factors for cost of acute and sub-acute inpatient services for stroke patients. MATERIAL AND METHOD The present study design was prevalence-based cost-of-illness with micro-costing approach. Subjects were 407 first episode stroke patients. Patien...