The clinical picture of Guillain–Barré syndrome (GBS) was first clearly described by Landry in 1856 [1]. Although he examined the nerves post-mortem, he did not find any abnormalities. The causative inflammation of the peripheral nerves was not identified until Leyden’s description in 1880 [2]. During the second half of the 19th century, confusion continued whether acute ascending paralysis was...

UNLABELLED Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy of motor and sensory impairment with distal predominance. Atrophy and weakness of lower limbs are the first signs of the disease. It can be classified, with the aid of electromyography and nerve conduction studies, as demyelinating (CMT1) or axonal (CMT2). OBJECTIVE Clinical and neurophysiological investigation of a large...

Inflammatory neuropathies may be due to infection (with a specific casual agent identified) including Lyme disease, HIV, Leprosy, Herpes Zoster, Hepatitis B & C. The other group of are Autoimmune or possibly infectious (but with no specific causal infectious agent identified) including sarcoidosis, Guillain-Barre syndrome/ acute inflammatory demyelinating polyneuropathy ( AIDP), chronic in...

Abstract Introduction This article reports a case of the difficulty to differentiate between critical illness polyneuropathy and axonal Guillain–Barré syndrome when triggered by subarachnoid haemorrhage. Case report An 81-year-old man was admitted comatose (Glasgow coma scale score 4/15) after a subarachnoid haemorrhage. His neurological condition gradually improved with as best motor response ...

This report describes a 26 year old woman with a Coxsackie B virus infection complicated by an acute pandysautonomic and sensory neuropathy. Electrophysiological studies suggested an axonal neuropathy. A sural nerve biopsy performed early in the disease showed axonal degeneration with a virtual absence of unmyelinated fibres and moderate loss of myelinated fibres, mainly affecting the small fib...

Charcot-Marie-Tooth disease type 1C (CMT1C) is a dominantly inherited motor and sensory neuropathy. Despite human genetic evidence linking missense mutations in SIMPLE to CMT1C, the in vivo role of CMT1C-linked SIMPLE mutations remains undetermined. To investigate the molecular mechanism underlying CMT1C pathogenesis, we generated transgenic mice expressing either wild-type or CMT1C-linked W116...

Diabetes and cancer chemotherapies are often associated with painful neuropathy. The mechanisms underlying neuropathic pain remain poorly understood, and the current therapies have limited efficacy and are associated with dose-limiting side effects. We recently described the pharmacological characterization of cholest-4-en-3-one, oxime (TRO19622), a cholesterol-like compound, that significantly...

Introduction: Several chemotherapeutic agents are currently available for the management of various malignancies; however, many associated with adverse effects. A case thalidomide- induced polyneuropathy is described below. Case Description: 65year old man, a history secondary myelofibrosis in thalidomide, consulted 5months neuropathic pain and paresthesia both hands. On physical examination, h...