PURPOSE To establish a radiobiological basis for gated stereotactic body radiotherapy of primary and metastatic liver cancers using volumetric arc radiotherapy in a flattening filter free (FFF) mode. METHODS Human cervical carcinoma, SiHa, non-small cell lung carcinoma, H460, and Chinese hamster V79 cells were irradiated in a water bath with 6MV photons from a Varian TrueBeam linear accelerat...

INTRODUCTION Modulation of gene expression in response to ionizing radiation is of prime interest in the field of radiation biology. In most articles concerning biological responses to ionizing radiation, the findings of radiation-induced gene expression after irradiation at a lethal dose range (2-50 Gy) has been reported. Recently, the biological effect of low dose radiation on cellular respon...

We evaluated the growth of children with acute leukemia who received a bone marrow transplant (BMT) after preparation with hyperfractionated total body irradiation (TBI). Seventy-two patients (27 female and 45 male patients) with acute lymphoblastic leukemia (ALL; n = 39) or acute myelogenous leukemia (AML; n = 33) who were less than 14 years of age at BMT were studied. Before BMT all had recei...

Objective- The aim of this study was to demonstrate the efficacy MSCs transplantation in combination with low level laser irradiation (low level laser irradiation) in repair of experimental acute spinal cord injury. Design- Experimental study. Animals- 28 adult male Wistar Rats. Procedures- A ballon- compression technique was used to produce an injury at the T8-T9 level of spi...

UNLABELLED BACKGROUND Crew members on space missions inevitably are exposed to low background radiation and can receive much higher doses during solar particle events (SPE) that consist primarily of protons. Ionizing radiation could cause lung pathologies. Cell adhesion molecules (CAM) are believed to participate in fibrogenesis. Interactions between CAM and extracellular matrix (ECM) affect...

BACKGROUND The purpose of this article is to present preliminary results of simultaneous boost irradiation radiotherapy for locally advanced nasopharyngeal carcinoma (NPC). METHODS Fifty-eight patients who underwent simultaneous boost irradiation radiotherapy for NPC in Cancer Center of Sun Yat-sen University between September 2004 and December 2009 were eligible. Acute and late toxicities we...

FTER THE DISCOVERY that injection of syngeneic ( isologous ) bone marrow or spleen cells can antagonize both the acute lethal effectsl,2,a and the late leukemogenic effects4’5 of total body x-irradiation in mice, attempts to determine the mechanisms involved led to some conflicting conclusions.#{176}’7’8’9’10”1 As far as the acute lethal action of a single high dose of total body x-irradiation ...

FTER THE DISCOVERY that injection of syngeneic ( isologous ) bone marrow or spleen cells can antagonize both the acute lethal effectsl,2,a and the late leukemogenic effects4’5 of total body x-irradiation in mice, attempts to determine the mechanisms involved led to some conflicting conclusions.#{176}’7’8’9’10”1 As far as the acute lethal action of a single high dose of total body x-irradiation ...

Glaucoma is a neurodegenerative disease that results in the progressive decline and ultimate death of retinal ganglion cells (RGCs). While multiple risk factors are associated with glaucoma, the mechanisms leading to onset and progression of the disease remain unknown. Molecular analysis in various glaucoma models has revealed involvement of non-neuronal cell populations, including astrocytes, ...

To study the mechanism by which ultraviolet (UV) light inhibits DNA replication, we examined the effects of UV 254 nm irradiation on the replication of simian virus 40 (SV40) DNA and SV40-based plasmid in monkey cells. The study was designed to determine the relative contributions made by inhibition of replication initiation and chain elongation to the immediate inhibition of DNA replication fo...