It is unknown whether neutrophilic inflammations can be regulated by T cells. This question was analyzed by studying acute generalized exanthematous pustulosis (AGEP), which is a severe drug hypersensitivity resulting in intraepidermal or subcorneal sterile pustules. Recently, we found that drug-specific blood and skin T cells from AGEP patients secrete high levels of the potent neutrophil-attr...

initially only with palmoplantar pustular lesions. Dermatology 6. Ramirez F, Fowell DJ, Puklavec M, Simmonds S, Mason D. 1992; 185: 276–280. Glucocorticids promote a Th2 cytokine response by CD4 T cells in 3. Patrizi A, Di Lernia V, Neri I, Gherlinzoni F. Eosinophilic pustular vitro. J Immunol 1996; 156: 2406–2412. folliculitis (Ofuji’s disease) and non-Hodgkin lymphoma. Acta Derm Venereol (Sto...

We present a case of acute generalized exanthematous pustolosis (AGEP) induced by amoxicillin-clavulanate. Clinical diagnosis was confirmed by symptoms presentation and  histological features (Euroscar score point compatible with definite diagnosis). Patch testing performer six months later confirmed sensitization to the culprit drug and showed positivity also to other beta-lactam antibiotics (...