Background: Studies have shown that a circadian rhythm may exist in the onset of acute coronary syndromes. More studies are needed in the Indian population to confirm the existence of this circadian variation and add to the existing literature in the Indian population. Methods: Two hundred twenty consecutive patients with acute coronary syndromes, admitted to the coronary care unit were include...

The American Heart Association and the American College of Cardiology,1,2 the European Society of Cardiology3,4 and others5 have developed comprehensive guidelines for the in-hospital management of patients with ST-elevation myocardial infarction (STEMI)2 and for unstable angina (UA) and non–ST-elevation MI (NSTEMI).1 The International Liaison Committee on Resuscitation (ILCOR) Acute Coronary S...

Experimental models of atherogenesis have provided a growing body of information about molecular mechanisms of plaque growth; however, transition from coronary stability to instability is less well understood due to the lack of animal models reflective of human disease. The abrupt clinical presentation of acute coronary syndromes gives a strong signal of discontinuity in the natural history of ...

syndromes aims to identify those patients at greatest risk of recurrent ischaemic events who might benefit prognostically from further investigation and treatment. Unfortunately, however, none of the clinical or investigative markers currently available has suYcient diagnostic power to identify all high risk patients while excluding those at negligible risk. Moreover, for patients judged to be ...

A comprehensive appraisal was undertaken on behalf of the British Cardiac Society and the Royal College of Physicians of London to assess the use of clopidogrel in acute coronary syndromes. The appraisal was submitted to the National Institute for Clinical Excellence (NICE) in August 2003 and contributed to the development of the recently published guidelines for the use of clopidogrel in acute...

Acute coronary syndromes (ACS) comprise a spectrum of clinical conditions, initiated by rupture of an atherosclerotic coronary plaque with overlying acute thrombosis. The consequences of thrombosis include direct obstruction of blood flow to the coronary beds, as well as distal embolization of the platelet-rich thrombus. Both of these processes may lead to myocardial ischemia and may progress t...

Acute coronary syndromes (ACS), such as unstable angina, acute myocardial infarction, and sudden cardiac death, are commonly associated with the presence of vulnerable plaques in coronary arteries. Rupture or erosion of vulnerable plaques results in the formation of luminal thrombi due to the physical contact between platelets and thrombogenic elements within the atherosclerotic lesions. Consid...

obtained with the two different LMWHs; major chemical, biological and clinical differences exist between these LMWHs, and there has been much debate on this issue. We believe that pooling these data would have generated many more letters to the editor! There are few biological markers of prognosis in unstable angina. Our recent studies have focused attention on vWf as a new marker of potential ...

The American Heart Association and the American College of Cardiology,1,2 the European Society of Cardiology3,4 and others5 have developed comprehensive guidelines for the in-hospital management of patients with ST-elevation myocardial infarction (STEMI)2 and for unstable angina (UA) and non–ST-elevation MI (NSTEMI).1 The International Liaison Committee on Resuscitation (ILCOR) Acute Coronary S...

Statins are the main resource available to reduce LDL-cholesterol levels. Their continuous use decreases cardiovascular morbidity and mortality due to atherosclerosis. The administration of these medications demonstrated to be effective in primary and secondary prevention clinical trials in low and high risk patients. Specialists believe that a possible benefit of hypolipidemic therapy in preve...