Objective This study aimed to find out prevalence of Helicobacter pylori (H. pylori) in peptic ulcer disease (PUD) which is highly endemic disease in Kashmir.Method This study consisted of 50 PUD patients and 30 asymptomatic volunteers. Peptic ulcer was diagnosed by endoscopic examination and H. pylori was detected by histology (using Giemsa stain), one minute endoscopy room test (OMERT) and mo...

PURPOSE Despite the great advances in laparoscopic techniques, most active general surgeons do not apply laparoscopic surgery in the treatment of duodenal ulcer perforation when facing a real-life emergency. Therefore, our study was designed to evaluate the feasibility of laparoscopic surgery in duodenal ulcer perforation, and provide a step-by-step protocol with tips and recommendations for le...

INTRODUCTION: Mycolactones, secreted by Mycobacterium ulcerans, were previously believed to prevent super infection in Buruli ulcer lesions. However, little is known about secondary bacterial infections in these lesions. This study evaluated contaminating bacterial flora and their antibiotic susceptibility patterns in cases of previously untreated Buruli ulcer disease from three states in Sout...

The Helicobacter pylori toxin VacA causes vacuolar degeneration in mammalian cell lines in vitro and plays a key role in peptic ulcer disease. Two alleles, m1 and m2, of the mid-region of the vacA gene have been described, and the m2 cytotoxin always has been described as inactive in the in vitro HeLa cell assay. However, the m2 allele is associated with peptic ulcer and is prevalent in populat...

Extravasation of Adriamycin during i.v. infusion can cause serious local complications. We have used a rat skin model to study the protection afforded by dimethyl sulfoxide and alpha-tocopherol (vitamin E) against Adriamycin-induced skin necrosis. Topical daily application of 1 ml dimethyl sulfoxide for 2 days produced a small decrease in ulcer diameter of up to 11% at 2 weeks. Topical daily ap...

The usefulness of endoscopy in marginal ulcer bleeding has rarely been studied, and the optimal method for preventing rebleeding is unclear. Here we assessed the efficacy of endoscopy in marginal ulcer bleeding and examined the efficacy of proton pump inhibitors (PPIs) in the prevention of rebleeding. A total of 28 patients with marginal ulcer bleeding (21 men, 7 women; median age 58.5 years) w...

Infection of the stomach and proximal duodenum with Helicobacter pylori induces inflammation with associated changes in the mucosa. Alterations in mucus structure and function, surface epithelial cell integrity, mucosal blood flow, and local mucosal neural and hormonal status have been observed following this infection. A proportion of subjects infected with H pylori develop duodenal ulcer dise...

OBJECTIVE To determine the incidence and age distribution of peptic ulcer disease in adults in Gothenburg. DESIGN Retrospective study of patients with symptoms over one year. SETTING All gastroenterology and x ray departments. PATIENTS Any patient found to have an active ulcer crater during 1985. MAIN OUTCOME MEASURES Sex, age, past history of gastrointestinal ulcers, and smoking habit....

It is presented the comparative analysis of treatment of 56 patients receiving blockers of H2 receptors, inhibitors of proton pomp both antihelicobacter eradication, and 58 people which complex included vacuum therapy by an original technique. At vacuum therapy within the first week of treatment there came ulcer clarification, its granulation, there is an epithelization and scarring. After shor...

AimsOur aim was to comprehensively estimate the incidence of diabetic foot ulcer (DFU) recurrence and corresponding risk factors in two cohorts.MethodsProspective data from patients with active DFU diabetes centres Germany (GER, n = 222) Czech Republic (CZ, 99) were analysed. Crude cumulative incidences obtained. Additionally, time investigated using multivariate Cox models.Results69%(154) GER ...