Two cross-sectional and one longitudinal study of patients with rheumatoid arthritis showed that platelet number correlated with both clinical and laboratory parameters of disease activity, including erythrocyte sedimentation rate, zeta sedimentation ratio, viscosity of plasma and blood, white cell count, liver enzymes, rheumatoid factor, and several acute-phase proteins. There was also an inve...

some medicinal plants are a potential source of new drugs, in order to improve the treatment of chagas disease whose treatment is still a challenge. in this study, the in vitro anti-epimastigote activity of certain fractions of achillea biebersteinii, a. millefolium, satureja mutica and s. macrantha was evaluated. diethyl ether fractions of achillea species and acetone fractions of satureja spe...

Abstract Background Ustekinumab (UST) is an approved biologic for the treatment of adults with Crohn’s disease (CD). Through 16 weeks (wks), UST demonstrated high rates efficacy, low immunogenicity, and safety in paediatric patients (pts) similar to that observed adults.1 Here, we evaluated CD pts through 268 wks. Methods UniStar was a phase 1, multicentre, double-blind study (2-18 years old; b...

polyomaviruses may cause human disease, particularly in immunocompromised hosts. jcv, one of the members of polyomaviridae family, is the causative agent of the neurological disease progressive multifocal leukoencephalopathy (pml), which occurs mostly in immunocompromised patients. progressive multifocal leukoencephalopathy (pml) is a progressive demyelinating disorder of the central nervous sy...

abstract background ulcerative colitis (uc) is characterized by recurrent episodes of inflammation limited to the mucosal layer of the colon. calprotectin is a zinc and calcium binding protein derived from neutrophils and monocytes. it is easily detectable in tissue samples, body fluids, and stools, which makes it a potentially valuable marker of inflammation. the aim of the current study is to...