نتایج جستجو برای: active bone formation

تعداد نتایج: 1210715  

H. Jazdarreh M. Meskinfam M. S. Sadjadi,

Bone like hydroxyapatite (nHAp) was synthesized via an in situ biomimetic process in presence of wheat starch. The effect of polymer concentration alteration on the final structure of nHAp was investigated. Formation of the nHAp at room temperature was confirmed by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). Size and morphology of the nHAp samples were character...

Journal: :Molecular and cellular biology 2007
Mohammad Q Hassan Rahul Tare Suk Hee Lee Matthew Mandeville Brian Weiner Martin Montecino Andre J van Wijnen Janet L Stein Gary S Stein Jane B Lian

HOXA10 is necessary for embryonic patterning of skeletal elements, but its function in bone formation beyond this early developmental stage is unknown. Here we show that HOXA10 contributes to osteogenic lineage determination through activation of Runx2 and directly regulates osteoblastic phenotypic genes. In response to bone morphogenic protein BMP2, Hoxa10 is rapidly induced and functions to a...

Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption, and from the anti-tumor immune response. ...

2005
Dwight A. Towler

Cellular and molecular similarities between orthotopic versus heterotopic mineral deposition are beginning to emerge. During bone formation, the major orthotopic venue, two general mechanisms drive tissue mineralization1 (Table). With endochondral ossification, an avascular cartilaginous skeletal template is first established by chondrocytes; this cartilage template calcifies and is subsequentl...

Journal: :BMB reports 2010
Natalie A Sims Nicole C Walsh

Cytokines that bind to and signal through the gp130 co-receptor subunit include interleukin (IL)-6, IL-11, oncostatin M (OSM), leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), and ciliary neutrophic factor (CNTF). Apart from contributing to inflammation, gp130 signalling cytokines also function in the maintenance of bone homeostasis. Expression of each of these cytokines and their liga...

Journal: :The Journal of bone and joint surgery. British volume 1996
F Gouin N Passuti V Verriele J Delecrin J V Bainvel

We performed biopsies during reoperation for minor complications in two active young patients 9 and 19 months after massive bone allograft implantation for bone tumour. The grafts were dead and resorption-apposition activity, when present, was predominantly in subperiosteal areas. Inflammatory infiltration was very seldom found. Features considered as 'microfractures' or 'microcracks' were note...

Journal: :iranian journal of basic medical sciences 0
asgar emamgholi neuroscience research center, baqiyatallah university of medical science, tehran, iran microbial biotechnology, faculty of science, payame noor university, unit of tehran center, tehran, iran mohsen rahimi department of parasitology and mycology, school of medicine, baqiyatallah university of medical science, tehran, iran gholamreza kaka neuroscience research center, baqiyatallah university of medical science, tehran, iran seyed homayoon sadraie department of anatomy, school of medicine, baqiyatallah university of medical science, tehran, iran saleh najafi microbial biotechnology, faculty of science, payame noor university, unit of tehran center, tehran, iran

objective(s):various methods for repairing bone defects are presented. cell therapy is one of these methods. bone marrow stromal cells (bmscs) seem to be suitable for this purpose. on the other hand, lots of biomaterials are used to improve and repair the defect in the body, so in this study we tried to produce a similar structure to the bone by the chitosan and hydroxyapatite. materials and me...

Journal: :The Journal of bone and joint surgery. British volume 1985
S N Bell B J Dooley B M O'Brien N F Bright

A cortical bone graft on a muscle pedicle was taken from the ulna and transferred to bridge a complete defect of the radius in 16 dogs. In 14 control dogs a free graft was used, that is, one without a muscle pedicle. Union in the group with pedicle grafts was far superior to that in the group with free grafts, mainly because in those with pedicle grafts there was good subperiosteal new bone for...

2017
Pornkawee Charoenlarp Arun Kumar Rajendran Sachiko Iseki

Bone is a metabolically active organ that undergoes continuous remodeling throughout life. However, many complex skeletal defects such as large traumatic bone defects or extensive bone loss after tumor resection may cause failure of bone healing. Effective therapies for these conditions typically employ combinations of cells, scaffolds, and bioactive factors. In this review, we pay attention to...

Journal: :Frontiers in bioscience 2012
Howard A Morris Andrew G Turner Paul H Anderson

Vitamin D status relates to two bone diseases, osteomalacia and osteoporosis which arise from distinct pathophysiogical pathways. They can occur in children as well as adults. Osteomalacia or rickets arises from a delay in mineralization and can be caused by severe vitamin D deficiency where the key to curing osteomalacia is the endocrine action of circulating 1,25-dihydroxyvitamin D to normali...

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