Process for the conversion of cyclic amines into lactams" (2012).

Six new fluorinated thiosemicarbazones R‑C(R')=N-NH-C(S)NH(2) (R = 2,4-C(6)H(3)F(2), R' = H (1); R = 2,5-C(6)H(3)F(2), R' = H (2); R = 2,6-C(6)H(3)F(2), R' = H (3); R = 3,4-C(6)H(3)F(2), R' = H (4); R = 3,5-C(6)H(3)F(2), R' = H (5) and R = 4-C(6)H(4)F, R' = C(6)H(5), (6)) have been prepared. The molecular structures of compounds 1 to 6 have been determined.

Arabidopsis encodes four DICER-like (DCL) proteins. DCL1 produces miRNAs, DCL2 produces some virus-derived siRNAs, and DCL3 produces endogenous RDR2-dependent siRNAs, but the role of DCL4 is unknown. We show that DCL4 is the primary processor of endogenous RDR6-dependent trans-acting siRNAs (tasiRNAs). Molecular and phenotypic analyses of all dcl double mutants also revealed partially compensat...

Sports are spontaneous generators of stories. Through skill and chance, the script of each game is dynamically written in real time by players acting out possible trajectories allowed by a sport's rules. By properly characterizing a given sport's ecology of "game stories," we are able to capture the sport's capacity for unfolding interesting narratives, in part by contrasting them with random w...

Etiology and Therapy of Overt Homosexuality Lawrence C. Kolb, M.D. and Adelaide M. Johnson, M.D. Although the origin of latent homosexuality has been discussed frequently in psychoanalytic literature, there has been no definition of those factors that lead to the eruption of overt homosexuality. Many patients have strong latent homosexual impulses, but do not act out these impulses, just as man...

artemisia annua is still the only commercial source of artemisinin. to date, a number of biochemical and molecular studies about artemisinin’s biosynthetic pathway have been carried out. in metabolic engineering approach, isolation and characterization of promoters leads to an understanding of which cis-acting elements are responsible for the regulation of gene expression. dbr2 is a key enzyme ...

Objectives: The aim of the present study was to investigate immunotoxic effect of safranal (SAF), a main component of Crocus sativus essential oil, using Balb/c mice. Materials and Methods: SAF was administered intraperitoneally at doses of 0.1, 0.5 and 1 ml/kg for 3 weeks. Hystopathological examination of spleen and bone marrow, cellularity of spleen, delayed type of hypersensitivity (DTH) res...

Background: Hydatid cyst is the larval stage of the tape worm parasite, Echinococcus granulosus. Human is infected by ingestion of parasite ova excreted in dog feces. The anticancer activity of different antigens of hydatid cyst has been reported in the previous works. In this research, the role of immune system in induction of this anticancer activity has been investigated.Materials and Method...

rubella or german measles is a mild contagious disease in non-pregnant women, but in pregnant affected mother’s possibility of fetus infection in the first twelve weeks of gestation is 80%. between 13-14 weeks of gestation is 54% and by the end of the second trimester is 25%. if fetus gets infected severe anomalies will progress. at present no vaccination against rubella is begin envisaged by t...

to evaluatethe effects of supplementing diets of growing japanese quails (n=450; 7 days old) with chromium (cr) yeast and / or mannan oligosaccharides (mos) on productive performance, carcass traits and the immune system are reported. diets were a basal diet (control) or the basal diet supplemented with 600 mg cr-yeast/kg (cr 1), 1200 mg cr-yeast/kg (cr 2), 1.0 g mos/kg, cr 1 + mos or cr 2 + mo...