In the crystal of the title compound, C(24)H(22)NO(2) (+)·CF(3)SO(3) (-), adjacent cations and anions are connected through C-H⋯O, C-H⋯F and S-O⋯π inter-actions, while neighboring cations via π-π inter-actions [centroid-centroid distance = 3.962 (2) Å]. The acridine and benzene ring systems are oriented at a dihedral angle of 14.6 (1)°. The carboxyl group is twisted at an angle of 87.6 (1)° rel...

The present article reports on the design and the synthesis of a series of mono- and bis-pyrimidinoacridines and their evaluation as a novel family of quadruplex-binders. It is shown that bispyrimidinoacridines represent an interesting compromise between easy synthetic access and efficiency in terms of quadruplex interaction (both affinic and selective), as judged by G4-FID assay and molecular ...

Several optical and hydrodynamic properties of purified nucleohistone have indicated that the secondary structure of DNA in nucleohistone is slightly different both from the structures of native and denatured DNA in solution. It has been suggested that while histones stabilize the overall DNA-structure they incorporate into the latter some denaturation defects. Rotational diffusion studies of a...

A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.

In this study, silica nanoparticles were used as support to prepare a new heterogeneous catalyst system for application in organic reactions. The reaction of silica nanoparticles with sodium 2-bromoethane-1-sulfonate resulted in the connection of a sulfonic acid group on the surface of silica nanoparticles (NSESA). The synthetic catalyst system was characterized using different microscopic and ...

It has been found that, like Atabrine, the phenothiazine tranquilizers promazine, chlorpromazine, promethazine, levopromethazine, and Stelazine; the antidepressants (dibenz-azepine and dibenzocycloheptene derivatives) Tofranil, Pertofrane, cyclobenzaprine, Elavil, protriptyline, and 3-chlorodibenzocycloheptene; and the acridine derivatives acridine orange, acriflavin, SKF no. 16214-A2, SKF no. ...