AAC03727-14R1 1 2 Moraxella catarrhalis AcrAB-OprM efflux pump contributes to antimicrobial 3 resistance and is enhanced during the cold shock response 4 5 6 7 Violeta Spaniol, Sara Bernhard, Christoph Aebi 8 9 10 Institute for Infectious Diseases, University of Bern, CH-3010 Bern, Switzerland, 11 Department of Pediatrics, University of Bern, Inselspital, CH-3010 Bern, Switzerland 12 13 14 Runn...

Pneumonia associated with Iegionnaires's disease is initiated in humans after inhalation of contaminated aerosols. In the environment, Legionella pneumophila is thought to survive and multiply as an intracellular parasite within free-living amoeba. In the genome of L. pneumophila Lens, we identified a unique gene, tolC, encoding a protein that is highly homologous to the outer membrane protein ...

A carbapenem resistant but ceftriaxone and cefepime susceptible Klebsiella oxytoca was isolated from the blood of a patient with polymicrobial bacteremia after 2 weeks of ertapenem treatment. Whole-genome sequencing identified no carbapenemase gene nor plasmid, but only blaOXY-2-8 gene with a mutation in the promoter that's been reported to increase its expression. Two other specific carbapenem...

Bacterial heteroresistance has been identified in several combinations of bacteria and antibiotics, and it complicated the therapeutic strategies. Tigecycline is being used as one of the optimal options for the treatment of infections caused by multidrug-resistant Salmonella. This study investigated whether heterorresistance to tigecycline exists in a Salmonella enterica serovar Typhimurium str...