BACKGROUND Systemic and topical antimicrobials are effective in the treatment of inflammatory acne vulgaris; however, widespread use of these agents is becoming increasingly associated with the emergence of resistant pathogens raising concerns about microorganism resistance and highlighting the need for alternative nonantimicrobial agents for the treatment of acne. Nicotinamide gel provides pot...

Acne vulgaris is a common inflammatory skin condition. Although often perceived as a self limited disease of adolescence, its prevalence remains high into adulthood. Nearly 90% of teenagers have acne, and half of them continue to experience symptoms as adults. By age 40 years, 1% of men and 5% of women still have lesions. Recent analyses show an increasing prevalence of acne in children, perhap...

Acne is one of the most common skin disorders. It is a multifactorial and complex disease, originating in the pilosebaceous follicle where a hereditary background, androgens, skin lipids, disorders of keratinization, inflammatory signaling, and regulatory neuropeptides seem to be mainly involved. Even though emotional stress has long been suspected to trigger or exacerbate acne, its influence o...

Acne vulgaris is a common dermatological disorder with a multifactorial pathogenesis. Oxidative status has been implicated in the pathogenesis of several skin diseases, including acne. This study was aimed to investigate the levels of oxidative stress biomarkers in acne vulgaris patients with varying severities. The study involved 156 patients with acne and 46 healthy human controls. Based on c...

OBJECTIVE To quantitatively document the presence and extent of a late luteal (premenstrual) acne flare in adult women. DESIGN Case series. SETTING Subjects were recruited from a general community dermatology practice and by advertising. SUBJECTS Adult women 18 to 44 years old with normal periods who were receiving no treatment for their acne. MAIN OUTCOME MEASURES Acne lesion counts we...

Acne fulminans is a rare and serious condition characterized by the sudden onset of nodular and ulcerative acne lesions associated with systemic symptoms. It has been recognized a subset of patients with a sudden worsening of acne, often during treatment with oral isotretinoin, but without the strong presence of systemic involvement. Recognized by some authors as "pseudo-acne fulminans" or " ac...

Acne is the most common dermatologic condition encountered in clinical practice, affecting nearly all adolescents and young adults to some degree. The pathophysiology of acne is complex. Increased sebum production by sebaceous glands and abnormal desquamation of hair follicles occur in response to increasing androgen levels with the onset of puberty. Obstruction of follicles causes follicular d...

introduction: acne scar is formed after severe episodes of acne in teen and earlyadult years. several treatment options have been used for depressed acne scars suchas punch grafting, punch excision carbon dioxide (co2) laser etc. moreover, studiesshow that laser skin resurfacing such as co2 fractional can effectively treat depressedacne scars. we investigated the efficacy of fractional co2 lase...

interleukin-8 (il-8) is a well-known inflammatory chemokine and suggested to be involved in the development of acne vulgaris. this study investigates il-8 plasma levels in acne patients and healthy controls and the molecular basis for the regulation of the il-8 gene in a pakistani population.patients with acne vulgaris (n=264) and healthy individuals (n=264) were enrolled in this investigation....

BACKGROUND Acne is the most common skin disease, affecting nearly 85% of the population as well as their lives. Acne can severely affect social and psychological functioning. Patients with acne may have anxiety, depression, decreased self-esteem, interpersonal difficulties, unemployment, social withdrawal, and even suicidal intent. AIMS The aim of this study was to evaluate the temperament an...