We describe a 21 month old male infant who presented with failure to thrive associated with severe hypokalaemia and metabolic acidosis, together with hypomagnesaemia. Evaluation revealed marked renal and probable faecal potassium wasting, distal renal tubular acidosis, mild urinary magnesium wasting, and a normal gastric pH (gastric H(+)-K(+)-ATPase). Hypokalaemic forms of metabolic acidosis, s...

1. Metabolic acidosis invariably accompanies chronic renal failure, and short periods of metabolic acidosis cause renal growth and proteinuria in normal rats. Rates of ammoniagenesis are increased in chronic renal failure, and it has been suggested that this contributes to disease progression. This study assessed (i) whether prolonged acidosis causes chronic renal injury in the normal kidney an...

OBJECTIVE To review the term hyperchloraemic acidosis. DATA SOURCES Articles and reviews from peer reviewed journals on acid-base physiology. SUMMARY OF REVIEW The concept of hyperchloraemic acidosis is well established in medicine and regularly taught to medical students. Unfortunately, it is yet another medical misnomer. Hyperchloraemic acidosis is only likely to exist with normal plasma ...

Serum concentrations of bile acids and tyrosine were determined in 14 premature infants with late metabolic acidosis and in 13 comparable controls without acidosis (protein intake 2 g/kg X d). At the same time the bile acids and the catalytic activity concentrations of lipase and trypsin were estimated in the duodenal juice. The daily faecal excretion and the percentage of fat eliminated were m...

The effects of acidosis on cardiac electrophysiology and excitation-contraction coupling have been studied extensively. Acidosis decreases the strength of contraction and leads to altered calcium transients as a net result of complex interactions between protons and a variety of intracellular processes. The relative contributions of each of the changes under acidosis are difficult to establish ...

neonatal respiratory distress is a very common problem in our practice. the causes may be respiratory, cardiovascular, central, metabolic, haematological and surgical. the cause of distress due to transient myocardial depression is not very common in mild asphyxia. we present a case having transient myocardial depression with severe respiratory distress and features of shock in a mild asphyxiat...

objective: this prospective study performed to evaluate blood biomarkers alterations with administration of propofol for maintenance of anaesthesia during long oral and maxillofacial surgeries in order to estimate the risk of propofol infusion syndrome (pris). this rare syndrome often would be happened in long duration or high dose infusion which is characterized by the combination of metabolic...

during a six year period (1969-1974), 29,233 records of the hospital admissions were carefully reviewed from the standpoint of age, sex incidence, precipitating factors, method of treatment and results in diabetes and diabetic coma patients in the isfahan university medical school’s hospitals. two hundred and fifty cases of diabetic patients were found (0.8% of the total), from which 25 (8%) we...

mote the increased atherosclerosis described in CKD [12] . Observational studies show that low serum [HCO 3 ] is associated with increased incidence of hypertension [13] , a major contributor to cardiovascular disease. In addition, high dietary acid increases the risk for CKD patients with reduced GFR to develop metabolic acidosis [14] and increases the risk for subsequent development of hypert...