نتایج جستجو برای: acetylcholinesterase ache

تعداد نتایج: 9824  

2017
Leyla Polat Köse

Lignans are a large group of chemical compounds found in plants. They have effects on enzymes, protein synthesis, cell proliferation, angiogenesis, growth factor and cell differentiation. In this study, inhibition effects of α-(-)-conidendrin, enterodiole, enterolactone, nordihydroguaiaretic acid, secoisolariciresinol and secoisolariciresinol diglucoside against carbonic anhydrase I and II isoe...

Journal: :Indian journal of physiology and pharmacology 2005
K Bharavi K S Reddy

To elucidate the role of acetylcholinesterase (AChE) enzyme in BBB function, phosalone, an organophosphorous compound, was studied using rat brain micro vessels in vitro. Phosalone at 100 mg/kg b. wt. induced convulsions and caused a significant inhibition of AChE resulting in increased permeability as assessed by volume distribution. The anaesthetized phosalone treated group also increased per...

Journal: :Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1992
D D Pavlov G M Chuiko Y V Gerassimov V D Tonkopiy

1. Bream (Abramis brama) were exposed to sublethal concentration of organophosphorus insecticide DDVP and the amount of food consumed and brain acetylcholinesterase (AChE) examined in exposed fish. 2. Exposure to DDVP resulted in decreased amount of food consumed and inhibited brain AChE activity. 3. Intraperitoneal injection of the fish with cholinergic drugs, atropine and TMB-4 recovered the ...

Journal: :Cumhuriyet Science Journal 2022

Acetylcholinesterase enzyme (AChE) is the that catalyzes hydrolysis of neurotransmitter acetylcholine to choline. Inhibitors this (AChE-i) are used treat Alzheimer's, a neurodegenerative disease. Due side effects drugs used, there has been an increased interest in investigating inhibitory potentials natural products which presumed have fewer effects. For purpose, highland honey, chestnut royal ...

2008
C. Luo

Inhibition of synaptic acetylcholinesterase (AChE) by organophosphate (OP) nerve agents is the main reason for their toxicity. Oximes are used as antidotes to reactivate nerve agent-inhibited AChE. To understand the mechanism of oxime-induced reactivation, we generated several mutant AChEs. Reactivation studies conducted with wild-type and mutant AChEs revealed that the peripheral anionic site ...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003
Talma Brenner Yasmine Hamra-Amitay Tama Evron Neli Boneva Shlomo Seidman Hermona Soreq

Alternative splicing induces, under abnormal cholinergic neurotransmission, overproduction of the rare "readthrough" acetylcholinesterase variant AChE-R. We explored the pathophysiological relevance of this phenomenon in patients with myasthenia gravis (MG) and rats with experimental autoimmune MG (EAMG), neuromuscular junction diseases with depleted acetylcholine receptors. In MG and EAMG, we ...

2013
Ashwani Kumar Sandeep Jain Milind Parle Neelam Jain Parvin Kumar

A series of 3-aryl-1-phenyl-1H-pyrazole derivatives was synthesized in good yield and assayed in vitro as inhibitors of the mice acetylcholinesterase (AChE) and two goat liver monoamine oxidase (MAO) isoforms, MAO-A and MAO-B. Most of the compounds demonstrated a good AChE and selective MAO-B inhibitory activities in the nanomolar or low micromolar range. N-((3-(4-chlorophenyl)-1-phenyl-1H-pyra...

2014
Sung Ryul Lee Julius Ryan D. Pronto Bolor-Erdene Sarankhuu Kyung Soo Ko Byoung Doo Rhee Nari Kim Natalia P. Mishchenko Sergey A. Fedoreyev Valentin A. Stonik Jin Han

Echinochrome A (EchA) is a dark-red pigment of the polyhydroxynaphthoquinone class isolated from sea urchin Scaphechinus mirabilis. Acetylcholinesterase (AChE) inhibitors are used in the treatment of various neuromuscular disorders, and are considered as strong therapeutic agents for the treatment of Alzheimer's disease (AD). Although EchA is clinically used to treat ophthalmic diseases and lim...

Journal: :Journal of cell science 1978
J A Watts S K Pierce

The presence of cholinesterase activity in M. demissus hearts was demonstrated by light- and electron-microscopic histochemistry and by enzymic assay. The enzyme proved to be acetylcholinesterase (AChE) since acetylthiocholine was the preferred substrate, and eserine or BW284C5I inhibited the enzyme activity, while isoOMPA was without effect. The AChE was localized and uniformly distributed alo...

1999

Acetylcholinesterase (AChE) inhibitors, including PB, produce acute destructive changes at the neuromuscular junction, the site of connection between nerve cells and muscle fibers, at which nerve cells signal muscles to contract. Because studies of the neuromuscular junction require microscopic inspection of muscle tissue and tests of electrical and chemical properties of the neuromuscular junc...

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