نتایج جستجو برای: acetyl coa carboxylase alpha gene
تعداد نتایج: 1331847 فیلتر نتایج به سال:
Acetyl-CoA carboxylase (ACC), an important enzyme in fatty acid biosynthesis and a regulator of fatty acid oxidation, is present in at least two isoenzymic forms in rat and human tissues. Previous work has established the existence of a 265,000 Da enzyme in both the rat and human (RACC265; HACC265) and a higher-molecular-mass species (275,000-280,000 Da) in the same species (RACC280; HACC275). ...
Studies presented here, with the criterion of the degree of binding of the biotin derivatives obtained from acetyl coenzyme A carboxylase to avidin, show that these compounds have an intact ureido ring, eliminating the diamine derivative as an intermediate in the carboxylation. With the use of carboxyl-14C-biotin acetyland propionyl-CoA carboxylases, it has been possible to show both in vivo an...
Acetyl-CoA carboxylase (E.C. 6.4.1.2) was isolated from rat liver. The purified enzyme contains phospholipids with a rather large amount of phosphatidylinositol (26%). Incubation of the purified acetyl-CoA carboxylase with phospholipase A2 (E.C. 3.1.1.4) or with phospholipase D (E.C. 3.1.1.4) diminishes the phospholipid content by 70%, this treatment leading to a complete inactivation of the en...
The main lipogenic tissues of the rat are the liver, white adipose tissue and, during lactation, the mammary gland. The rate of fatty acid synthesis de novo in these tissues must be regulated according to the nutritional and physiological status of the animal. Such short-term regulation is primarily achieved through the action of hormones. Acetyl-CoA carboxyulase is a prime target for such horm...
Acetyl-CoA carboxylase-α (ACC-α) is a key enzyme in the regulation of fatty acid synthesis and is subject to both acute control, via reversible phosphorylation, and chronic control that results in the regulation of synthesis of the enzyme. The gene for ACCα is expressed ubiquitously, but expression is highest in lipogenic tissues: adipose, liver, and lactating mammary gland. These tissues demon...
Acetyl CoA carboxylase (ACC) 2, which catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA, has been identified as a potential target for type 2 diabetes and obesity. Small-molecule inhibitors of ACC2 would be expected to reduce de novo lipid synthesis and increase lipid oxidation. Treatment of ob/ob mice with compound A-908292 (S) ({(S)-3-[2-(4-isopropoxy-phenoxy)-thiazol-5-yl]-1-meth...
Activation of adenosine monophosphate-activated protein kinase (AMPK) plays a central role in allowing cells to adapt to nutrient deprivation in vitro. This link between AMPK activity and nutritional status has raised the possibility that AMPK plays a role in the metabolic adaptation to acute and chronic nutritional stress. However, the effects of nutritional stress on AMPK activity in vivo hav...
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