Ischemic heart disease is the most common underlying cause of congestive heart failure, and thus aspirin (acetylsalicylic acid [ASA]) and angiotensin-converting enzyme (ACE) inhibitors are commonly used together for treatment in this setting. The issue of possible attenuation of the effect of ACE inhibitors by ASA has been an area of intense debate. Currently, it is perceived that a significant...

Cardiologists and generalists have been reported to diverge in terms of their self-reported use of angiotensinconverting enzyme (ACE) inhibitors, but information on their actual use of ACE inhibitors has been lacking. In order to assess ACE inhibitor use in patients with heart failure in a teaching hospital and any diVerences between specialties we studied all patients in the Western Infirmary ...

Recently, many concerns are paid for dual action drugs such as ACE/NEP dual inhibitors which have two different biological activities. To identify multiple active drugs by supervised learning approach, a multi-label classification technique is required. In the present work, we investigated the classification of antihypertensive drugs including ACE/NEP dual inhibitors using support vector machin...

Q:Should I avoid angiotensin-converting enzyme (ACE) inhibitors in my patients with progressive renal insufficiency? A:This issue is extremely bothersome to clinicians. ACE inhibitors represent a dual-edged sword with respect to their impact on renal function. On one hand, major clinical trials have clearly demonstrated their benefit in patients with congestive heart failure (CHF) and in patien...

BACKGROUND The relative effectiveness of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) for lowering blood pressure is unknown. PURPOSE To compare the benefits and harms of ACE inhibitors versus ARBs for treating essential hypertension in adults. DATA SOURCES MEDLINE (1966 to May 2006), the Cochrane Central Register of Controlled Trials (Issue 2, ...

The control of mosquitoes is threatened by the appearance of insecticide resistance and therefore new control chemicals are urgently required. Here we show that inhibitors of mosquito peptidyl dipeptidase, a peptidase related to mammalian angiotensin-converting enzyme (ACE), are insecticidal to larvae of the mosquitoes, Aedes aegypti and Anopheles gambiae. ACE inhibitors (captopril, fosinopril ...

Despite the huge amount of studies looking for candidate genes, the ACE gene remains the unique, well-characterized locus clearly associated with pathogenesis and progression of chronic kidney disease, and with response to treatment with drugs that directly interfere with the renin angiotensin system (RAS), such as angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor antag...

Angiotensin-converting enzyme (ACE) inhibitors frequently are prescribed for the management of cardiovascular disorders. In addition to their therapeutic potential, ACE inhibitors are associated with numerous adverse effects, some of which may be lethal. Angioedema is an uncommon but serious acute event that may affect any individual taking an ACE inhibitor. This review outlines the advances in...

AIMS Angiotensin-converting enzyme (ACE), which metabolizes many peptides and plays a key role in blood pressure regulation and vascular remodeling, is expressed as a type-1 membrane glycoprotein on the surface of different cells, including endothelial cells of the heart. We hypothesized that the local conformation and, therefore, the properties of heart ACE could differ from lung ACE due to di...

ACE inhibitor drugs decrease mortality by up to one-fifth in cardiovascular patients. Surprisingly, there are reports dating back to 1979 suggesting the existence of endogenous ACE inhibitors. Here we investigated the clinical significance of this potential endogenous ACE inhibition. ACE concentration and activity was measured in patient's serum samples (n = 151). ACE concentration was found to...