Liver acetyl-CoA carboxylase, a biotin-enzyme which catalyzes the ATP-dependent carboxylation of acetyl-CoA (acceptor) to form malonyl-CoA (carboxylated acceptor), decarboxylates malonyl-CoA by a biotin-dependent, as well as a biotin-independent mechanism. Neither ADP, Pi, nor divalent metal ion are required for either of these abortive decarboxylations. The biotin-dependent reaction is blocked...

Liver acetyl-CoA carboxylase, a biotin-enzyme which catalyzes the ATP-dependent carboxylation of acetyl-CoA (acceptor) to form malonyl-CoA (carboxylated acceptor), decarboxylates malonyl-CoA by a biotin-dependent, as well as a biotin-independent mechanism. Neither ADP, Pi, nor divalent metal ion are required for either of these abortive decarboxylations. The biotin-dependent reaction is blocked...

Semiconductor nanocrystals, also known as quantum dots (QDs), have emerged as a significant new class of materials over the past decade. The capabilities of QDs – high quantum yield, improved sensitivity, high photostability, and size-tunable colors have paved the way for numerous studies including imaging, sensing and targeting biomolecules. Thus QDs are now rapidly replacing traditional fluor...

A novel organic dianion, N,N'-Disulfo-1,4-benzoquinonediimine (1) has been prepared, which is a strong electron acceptor. The reduction potential of the PPh4 salt indicates that 1 is a stronger acceptor than DDQ (2,3-dichloro-5,6-dicyano-1,4benzoquinone). The dianionic acceptor provided a BEDT-TTF salt, (BEDT-TTF)41·3H2O, the structures and physical properties of which are reported.

The Acceptor-Connector design pattern decouples connection establishment and service initialization in a distributed system from the processing performed once a service is initialized. This decoupling is achieved with three components: acceptors, connectors, and service handlers. A connector actively establishes a connection with a remote acceptor component and initializes a service handler to ...

Förster-type nonradiative energy transfer (NRET) is widely used, especially utilizing nanostructures in different combinations and configurations. However, the existing well-accepted Förster theory is only for the case of a single particle serving as a donor together with another particle serving as an acceptor. There are also other special cases previously studied; however, there is no complet...

Abstract Electronic interactions in donor-π-linker-acceptor systems with barbituric acid as an electron acceptor and possible donor were investigated to screen promising candidates a push–pull character based on experimental quantum chemical studies. The tautomeric properties of 5-benzylidenebarbituric derivatives studied NMR spectra, spectrophotometric determination the pKa values, calculation...

The current drug research techniques, combinatorial synthesis and high throughput screening, help in obtaining pre-evaluating thousands of compounds a short duration time. Among the selected compounds, best hit molecule becomes lead, likeness property helps to optimize selection. Lipinski's Rule five is most widely used filter pre-evaluation according with poor oral absorption low permeation ha...