Pseudouridylation, the isomerization of uridine to pseudouridine, is the most frequent post‐ transcriptional modification of RNA, such that pseudouridine has even been termed the fifth nucleotide. Whereas eubacteria employ single protein enzymes to identify and modify target uridines, archaebacteria and eukaryotes additionally evolved more complex modification machines, H/ACA ribonucleoproteins...

Zhuo JL, Carretero OA, Peng H, Li XC, Regoli D, Neugebauer W, Rhaleb NE. Characterization and localization of Ac-SDKP receptor binding sites using I-labeled Hpp-Aca-SDKP in rat cardiac fibroblasts. Am J Physiol Heart Circ Physiol 292: H984–H993, 2007. First published October 6, 2006; doi:10.1152/ajpheart.00776.2006.—We have shown that the tetrapeptide N-acetyl-seryl-aspartyl-lysyl-proline (Ac-S...

BACKGROUND Morbidity and mortality after resuscitation largely depend on the recovery of brain function. Ventricular fibrillation cardiac arrest (VFCA) and asphyxial cardiac arrest (ACA) are the two most prevalent causes of sudden cardiac death. Up to now, most studies have focused on VFCA. However, results from the two models have been largely variable. So, it is necessary to characterize the ...

CONTEXT The Patient Protection and Affordable Care Act (ACA) is changing the landscape of health systems across the United States, as well as the functioning of governmental public health departments. As a result, local health departments are reevaluating their roles, objectives, and the services they provide. OBJECTIVE We gathered perspectives on the current and future impact of the ACA on g...

(ACA)-anterior communicating artery (AComA) complex are commonly identified at imaging studies, an infraoptic ACA is extremely rare (1-4). In such cases, an anomalous vessel originates from the internal carotid artery (ICA) at the level of the ophthalmic artery, and then pursues an infraoptic and prechiasmatic path to supply the ACA. We describe a case of in which this anomaly coexisted with a ...

In my preliminary article of this series, I explained that the Affordable Care Act (ACA) can be split into two rough sections: improving the quality of health care services and reducing the cost of care. With that as a framework, this series provides brief explanations of various components of the ACA, alternating between quality and financial initiatives. This installment takes a closer look a...

This work aims to construct an artificial neural network (ANN) ant colony algorithm (ACA)-based fine recognition system for plant factory seedling phenotypes. To address the problems of complexity and high delay in factories, first, multiple cameras at different positions are employed collect images seedlings 3D images. Then, mask region convolutional networks (MRCNN) is adopted analyze Finally...

[Ag(2)(9-aca)(2)] (1) (9-acaH = 9-anthracenecarboxylic acid) reacts with a series of imidazoles to give [Ag(imidH)(2.3)(CH(3)CN)(0.7)](9-aca) (3), [Ag(6)(imidH)(4)(9-aca)(6)(MeOH)(2)] (4), {[Ag(1-Me-imid)(2)](2)[Ag(4)(9-aca)(6)]} (5), {[Ag(1-Bu-imid)(2)](2)[Ag(4)(9-aca)(6)]} (6) and [Ag(apim)](9-aca)·H(2)O (7) (imidH = imidazole; 1-Me-imid = 1-methylimidazole; 1-Bu-imid = 1-butylimidazole; apim...

OBJECTIVE To identify genetic associations between allograft inflammatory factor 1 (AIF1) and systemic sclerosis (SSc), or its subsets, using a single nucleotide polymorphism (SNP) in a replicate case-control study. METHODS The frequencies of alleles and genotypes of an SNP, rs2269475, for the AIF1 gene were examined in two large independent cohorts of SSc patients (n = 1015 total), and compa...

As the primary healthcare providers for women, obstetrician-gynecologists' (OB/GYNs) experiences with and opinions about the Affordable Care Act (ACA) are important to understand. An online survey was sent to 1000 randomly selected OB/GYNs who were members of the American College of Obstetricians and Gynecologists (ACOG) in 2014. Of those, 523 opened the email and 163 responded (31% participati...