HsTX1 toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. Here we describe new HsTX1 analogues with an Ala, Phe, Val or Abu substitution at position 14. Complexes of HsTX1 with the voltage-gated potassium channels Kv1.3 and Kv1.1 were created using docking and molecular dynamics simulations, then umbrella sampli...

Alpha-lipoic acid (ALA) is a naturally-occurring compound that has shown promising antioxidant and anti-inflammatory effects in experimental and human studies. The aim of this study was to assess the efficacy of ALA in the management of patients with diabetes mellitus (DM).We searched Medline (via PubMed), EBSCO, Scopus, and Web of Science for relevant randomized controlled trials. Data o...

1 Center for Genomics and Systems Biology, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates, 2 Ecological Marine Services, Millbank, QLD, Australia, 3 Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark, 4 NOAA/NESDIS/STAR Coral Reef Watch, College Park, MD, United States, 5 Marine Geophysical Laboratory, Physics Department, College of Science and Engi...

bacterial penicillin-binding proteins and beta-lactamases. Antimicrob. Agents Chemother. 42(1), 1 17. [41] Davies, C., White, S.W., Nicholas, R.A. (2001). Crystal structure of a deacylation-defective mutant of penicillin-binding protein 5 at 2.3-Å resolution. J. Biol. Chem. 276(1), 616 623. [42] Nicola, G., Tomberg, J., Pratt, R.F., Nicholas, R.A., Davies, C. (2010). Crystal structures of coval...

Background: 5-aminolevulinic acid (5-ALA) has a poor penetrance of the skin with topical application, which reduces efficacy Photodynamic therapy (PDT). Sonophoresis involves use sound waves or ultrasonic energy to enhance transdermal delivery drugs. The purpose this study was investigate effects sonophoresis on penetration 5-ALA into skin. Methods: We calculatedin vitrotransdermal accumulation...

It has been recently suggested by Arkani-Hamed, Dimopoulos and Dvali that gravity may become strong at energies not far above the electroweak scale and thus remove the hierarchy problem. Such a scenario can be tested at both present and future accelerators since towers of Kaluza-Klein gravitons and associated scalar fields now play an important phenomenological role. In this paper we examine se...

In this paper, we investigate the bulk service queue with Bernoulli vacation schedule and restricted admissibility introduced and studied by Madan and Abu-Dayyeh, [Revista Investigacion Operacional, Vol.24, No.2, pp.113-123, 2003]. Madan and Abu-Dayyeh assume exponentially distributed service times while we allow these times to be generally distributed. We obtain various performance measures th...

Moment invariants are evaluated as a feature space for pattern recognition in terms of discrimination power and noise tolerance. The notion of complex moments is introduced as a simple and straightforward way to derive moment invariants. Through this relation, properties of complex moments are used to characterize moment invariants. Aspects of information loss, suppression, and redundancy encou...