The investigations of ultimobranchial tissue still remain to be some contradictory questions on its fate and function. Some investigators insist the contribution of ultimobranchial tissue to formation of thyroid tissue and some others deny it. Autoradiographic studies using radioiodine (Gorbman, '47) elucidated a fact in mice that the follicles of ultimobranchial origin are not able to collect ...

Ectopic thyroid tissue is an uncommon embryologic aberration characterized by the presence of thyroid tissue in a site other than its usual pre-tracheal location. Single ectopic thyroid tissue is the most common variant, and the base of the tongue is the most frequent ectopic location. Dual ectopic thyroid is extremely rare, and only eleven cases have been reported in the English literature. Fu...

background: there are inter-observer disagreements between papillary thyroid carcinoma (ptc) with other follicular lesions of thyroid in aspect of diagnosis. cd56 is present on follicular epithelial cells of the normal thyroid. we evaluated the diagnostic value of cd56 expression in ptc, follicular thyroid lesions, and follicular thyroid neoplasms. materials and methods: seventythree cases diag...

Overt hypothyroidism is diagnosed by a serum thyroid-stimulating hormone (TSH) concentration above the normal reference range and a serum free thyroxine (FT4) concentration below the reference range (BTA 2006). Clinical features may be absent or present. Subclinical hypothyroidism is diagnosed by a TSH concentration above the reference range with an FT4 concentration within the reference range ...

Thyroid adenomas (TA) are benign tumors, but there is a 20% possibility of malignant transformation. The distinguishing between the TA and thyroid cancer (TC) tricky, therefore new biomarkers needed. Furthermore, role chemical elements (ChE) in etiology pathogenesis unclear. aim this exploratory study was to evaluate whether significant changes tissue levels twenty Al, B, Ba, Br, Ca, Cl, Cu, Fe...

Ectopic thyroid tissue is seen rarely. It is often seen in cervical midline, and rarely in other areas such as submandibular area. Diagnosis is made histopathologically by fine needle biopsy after the elimination of malignancy. In the treatment of ectopic thyroid tissue, surgical excision is mostly applied. According to our knowledge, there is no exophytic thyroid tissue reported in the literat...

Metastatic prostate cancer is a terminal disease, and the development of reliable prognostic tools and more effective therapy is critically important for improved disease survival and management. This study was aimed at identifying genes that are differentially expressed in metastatic and nonmetastatic prostate cancer cells and, as such, could be critical in the development of metastasis. Long-...

Expression of the recently cloned Pendred syndrome gene SLC26A4 or PDS has been found to be decreased or even absent in various thyroid tumors. To explore the underlying mechanism, we conducted DNA sequencing and methylation-specific PCR studies in 64 primary thyroid tumors and 6 thyroid cell lines. We found aberrant hypermethylation of the SLC26A4 gene in 44% of histologically benign adenomas,...