Tumor progression is often associated with altered glycosylation of the cell-surface proteins and lipids. The peripheral part of these cell-surface glycoconjugates often carries carbohydrate structures related to the ABO and Lewis blood-group antigens. The expression of histo-blood-group antigens in normal human tissues is dependent on the type of differentiation of the epithelium. In most huma...

ABO antibodies (isoagglutinins) represent a formidable barrier to optimizing live donation and organ distribution. Blood group antigens are expressed on the endothelium of solid organs, and transplantation across a blood group barrier can result in hyperacute or acute antibody-mediated rejection (AMR). Based on blood group distributions in the United States, there is a 36% probability that any ...