BACKGROUND Abnormal cortical pain responses in patients with fibromyalgia and conversion disorder raise the possibility of a neurobiologic basis underlying so-called "functional" chronic pain. OBJECTIVE To use percept-related fMRI to test the hypothesis that patients with a painful functional bowel disorder do not process visceral input or sensations normally or effectively at the cortical le...

BackgroundPyridoxine monotherapy in PDE-ALDH7A1 often results adequate seizure control, but neurodevelopmental outcome varies. Detailed long-term neurological is unknown. Here we present the cognitive and features of Dutch cohort.MethodsNeurological was assessed 24 patients (age 1–26 years); classified as normal, complex minor dysfunction (complex MND) or abnormal. Intelligence quotient (IQ) de...

When people monitor a visual stream of rapidly presented stimuli for two targets (T1 and T2), they often miss T2 if it falls into a time window of about half a second after T1 onset--the attentional blink. However, if T2 immediately follows T1, performance is often reported being as good as that at long lags--the so-called Lag-1 sparing effect. Two experiments investigated the mechanisms underl...

Satisfaction of search (which we refer to as subsequent search misses)-a decrease in accuracy at detecting a second target after a first target has been found in a visual search-underlies real-world search errors (e.g., tumors may be missed in an X-ray if another tumor already has been found), but little is known about this phenomenon's cognitive underpinnings. In the present study, we examined...

Identification of the second of two targets is impaired if it is presented less than about 500 ms after the first. Three models of this second-target deficit, known as attentional blink (AB), were compared: resource-depletion, bottleneck, and temporary loss of control (TLC). Five experiments, in which three sequential targets were inserted in a stream of distractors, showed that identification ...

Three target words (T1, T2, and T3) were embedded in a rapid serial visual presentation (RSVP) stream of non-word distractors, and participants were required to report the targets at the end of each RSVP stream. T2 and T3 were semantically related words in half of the RSVP streams, and semantically unrelated words in the other half of the RSVP streams. Using an identical design, a recent study ...

Attentional blink (AB) describes the finding that, when subjects attend to a specified target in a rapidly presented visual stream, they show a decreased ability to process a subsequent probe item for up to 600 msec. In the present study, the roles of featural and conceptual interference in the processing of targets and probes in a rapid serial visual presentation stream were examined. In Exper...