OBJECTIVE The aim of this study was to examine cross-sectional associations between objectively measured sedentary time and magnetic resonance imaging (MRI)-assessed adiposity in a population at high risk for type 2 diabetes (T2DM) and to determine whether associations are modified by the recommended levels of moderate-to-vigorous physical activity (MVPA). METHODS Sedentary time and MVPA were...

In the brief exchange above, Jane and Mike’s intentions were to vent; to commiserate with one another, sharing some fairly detailed information on the challenges they face; and to bond by using “insider” terms. Here is a glossary of the slang terms that they used: • the hole: used by surgeons to describe the appearance of the operative field in an obese patient undergoing abdominal surgery, whe...

OBJECTIVES To investigate changes in the fat content of abdominal compartments and muscle area during weight loss using confounder-adjusted chemical-shift-encoded magnetic resonance imaging (MRI) in overweight diabetics. METHODS Twenty-nine obese diabetics (10/19 men/women, median age: 59.0 years, median body mass index (BMI): 34.0 kg/m2) prospectively joined a standardized 15-week weight-los...

OBJECTIVE Body fat redistribution ('lipodystrophy'), with gain in abdominal and trunk fat, and decline in facial and limb fat, is a newly recognized problem in patients with HIV infection that has been linked to use of HIV-1 protease inhibitors. Increased abdominal fat may predispose these patients to hypertension, diabetes, and coronary artery disease. At this time no effective treatment is av...

CONTEXT The increasing prevalence of obesity is a major public health concern. Physical activity may promote weight and body fat loss. OBJECTIVE To examine the effects of exercise on total and intra-abdominal body fat overall and by level of exercise. DESIGN Randomized controlled trial conducted from 1997 to 2001. SETTING AND PARTICIPANTS A total of 173 sedentary, overweight (body mass in...

Results A 16-week VLCD significantly reduced bodyweight, hepatic TG content, visceral and subcutaneous abdominal fat and pericardial fat volumes to 78, 16, 40, 55 and 83%, respectively, of baseline values (all p<0.05). After an additional 14 months of follow-up on a regular diet, weight and hepatic TG content increased significantly to 90 and 73% of baseline values (P<0.05). After these 14 mont...

In the early 1980s, we analyzed the metabolic profile of 930 men and women and concluded that an abdominal distribution of fat for a given BMI is associated with increased insulin resistance and risk of developing type 2 diabetes and cardiovascular disease. The correlation between abdominal fat and metabolic dysfunction has since been validated in many studies, and waist circumference is now a ...

OBJECTIVE Age-associated insulin resistance may be caused by increased visceral adiposity and older animals appear to be more susceptible to obesity-related resistance than young animals. However, it is unclear to what extent the portally drained mesenteric fat depot influences this susceptibility. RESEARCH DESIGN AND METHODS Young high-fat-fed and old obese rats were subjected to 0, 2, 4, or...