In this study, BevMab was conjugated with the bifunctional chelating agent [diethylenetriamine pentaacetic acid (DTPA)] and the product (BevMab-DTPA) was labeled with Tc using stannous chloride reducing method. The quality control studies of radiolabeled compound (Tc-BevMab-DTPA) were done with Thin Layer Radio Chromatography (TLRC) and High Performance Liquid Radio Chromatography (HPLRC) metho...

UNLABELLED The Auger electron-emitting radiopharmaceutical 111In-diethylenetriaminepentaacetic acid human epidermal growth factor (111In-DTPA-hEGF) binds the epidermal growth factor receptor (EGFR), is internalized, and translocates to the nucleus. The purpose of this study was to investigate the relationship between EGFR expression, DNA damage, and cytotoxicity in cells exposed to 111In-DTPA-h...

• Extracellular agents (such as Gd-DTPA) accumulate in the interstitium of many tissues (e.g. muscle) but do not cross the normal blood-brain-barrier. • Functional information may be obtained by treating Gd-DTPA as a tracer and following its kinetics (as opposed to the conventional ‘static’ approach, inject wait – image once). • After intravenous administration (normally in the form of a bolus)...

Purpose: Gd-EOB-DTPA is a liver-specific MR imaging contrast agent that is taken up by hepatocytes and excreted into the biliary system. MR cholangiography can be obtained by means of three-dimensional T1-weighted imaging at the optimal scan delay after the injection of Gd-EOB-DTPA (1). The aim of the present study was to evaluate the biliary enhancement dynamics of Gd-EOB-DTPA at MR cholangiog...

Cell tracking using iron oxide nanoparticles has been well established in MRI. However, in experimental rat models, the intrinsic iron signal derived from erythrocytes masks the labeled cells. The research evaluated a clinically applied Gd-DTPA for T1-weighted positive enhancement for cell tracking in spinal cord injury (SCI) rat models. MSCs were labeled with jetPEI/Gd-DTPA particles to evalua...

Mechanisms of increased epithelial lung clearance of DTPA in diffuse fibrosing alveolitis. S. Labrune, Th. Chinet, M.A. Collignon, L. Barritault, G.J. Huchon. ERS Journals Ltd 1994. ABSTRACT: The aim of this study was to elucidate possible mechanisms of increased epithelial lung clearance in diffuse fibrosing alveolitis (DFA). We investigated the relationships between epithelial lung clearance...

Accurate diagnosis in early stage is vital for the treatment of Hepatocellular carcinoma. The aim of this study was to investigate the potential of poly lactic acid-polyethylene glycol/gadolinium-diethylenetriamine-pentaacetic acid (PLA-PEG/Gd-DTPA) nanocomplexes using as biocompatible molecular magnetic resonance imaging (MRI) contrast agent. The PLA-PEG/Gd-DTPA nanocomplexes were obtained usi...

Fungal pathogens have evolved diverse strategies to sense host-relevant cues and coordinate cellular responses, which enable virulence and drug resistance. Defining circuitry controlling these traits opens new opportunities for chemical diversity in therapeutics, as the cognate inhibitors are rarely explored by conventional screening approaches. This has great potential to address the pressing ...

1. Tracer Kinetic Modeling • Extracellular agents (such as Gd-DTPA) accumulate in the interstitium of many tissues (e.g. muscle) but do not cross the healthy blood-brain-barrier. • Functional information may be obtained by treating Gd-DTPA as a tracer and following its kinetics (as opposed to the conventional ‘static’ approach, inject wait – image once). • After intravenous administration (norm...