objective(s): hypoxia is a serious challenge for treatment of solid tumors. this condition has been manifested to exert significant therapeutic effects on glioblastoma multiform or (who) astrocytoma grade iv. hypoxia contributes numerous changes in cellular mechanisms such as angiogenesis, metastasis and apoptosis evasion. furthermore, in molecular level, hypoxia can cause induction of dna brea...

  Objective(s): Hypoxia is a serious challenge for treatment of solid tumors. This condition has been manifested to exert significant therapeutic effects on glioblastoma multiform or (WHO) astrocytoma grade IV. Hypoxia contributes numerous changes in cellular mechanisms such as angiogenesis, metastasis and apoptosis evasion. Furthermore, in molecular level, hypoxia can cause induction of DNA br...

Dates fruit has been used as staple food in the Middle East for thousands of years and various types of dates are found worldwide. Dates and their constituents show various roles in diseases prevention and treatment through anti-oxidant, anti-inflammatory, anti-bacterial activity. In the present study we investigated the activity of aqueous and n-hexane extracts of Phoenix dactylifera L. fruit ...

هدف: RNA های غیرکدکننده از جمله مولکول تنظیم شناخته شده در سلول می باشند که فرایندهای مختلفی را کنترل کنند. مرتبط با مزبور، رشد و نمو تمایز سلولی باشد. این رو نقش آنها بروز تومور سرطان مختلف دست بررسی خصوص ارتباط مستقیمی بین ملکول مزبور دیده است. انواع غیر کد کننده ها، بلند (Long non-coding RNAs) باشند. گروه RNAها به‫عنوان کننده‌های کلیدی شده‫اند. ازجمله LncRNA MIAT یکRNA می‌باشد تقش انکوژنی آن...

Abstract ONC201 is the first bitopic dopamine receptor D2 (DRD2) antagonist and allosteric mitochondrial protease ClpP agonist. well tolerated induces durable tumor regressions in H3 K27M-mutant glioma patients. ONC206, a derivative of currently Phase I trials, also DRD2 agonist with enhanced nanomolar potency relative to ONC201. We evaluated vitro efficacy, mechanism(s) action acquired resista...

Abstract Background Gliomas account for the majority of fatal primary brain tumors, and there is much room research in underlying pathogenesis, multistep progression glioma, how to improve survival. In our study, we aimed identify potential biomarkers or therapeutic targets glioma study mechanism tumor progression. Methods We downloaded microarray datasets (GSE43378 GSE7696) from Gene Expressio...

Ginsenoside Rh2 (G‑Rh2), the main bioactive component in American ginseng, is known to exert a wide variety of biological activities. Accumulating evidence suggests that G‑Rh2 inhibits cell proliferation and induces apoptosis of tumor cells. However, the possible mechanism through which G‑Rh2 exerts its action on malignant glioma cells have not been completely elucidated. The findings of the pr...

Investigating the effect of low-dose radiation exposure on cells using assays of colony-forming ability requires large cell samples to maintain statistical accuracy. Manually counting the resulting colonies is a laborious task in which consistent objectivity is hard to achieve. This is true especially with some mammalian cell lines which form poorly defined or 'fuzzy' colonies, typified by glio...