Hypopharyngeal squamous cell carcinoma (SCC) is a rare form of malignancy and treatment approach is most commonly with chemo-radiotherapy or total pharyngolaryngoesophagectomy. We report a case of hypopharyngeal SCC managed with local resection and larynx preservation in a 77-year-old-woman. Total pharyngolaryngoesophagectomy renders patients with an alteration in both voice and ability to swal...

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain cancer, with a median survival of less than 2 years after diagnosis with current available therapies. The tumor microenvironment serves a critical role in tumor invasion and progression, with microglia as a critical player. Our laboratory has previously demonstrated that propentofylline, an atypical methylxanthine wit...

Gavin J. Miller,a Karl. R. Broberg,a Claire Rudd,a Madeleine R. Helliwell,c Gordon C. Jaysonb and John M. Gardiner*a a Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK. b Institute of Cancer Sciences, The University of Manchester, Wilmslow Road, Manchester M20 4BX, United Kingdom. c School of Chemistry, The Uni...

1 Sunderesh S. Heragu, Decision Sciences and Engineering Systems Department, Rensselaer Polytechnic Institute, Troy, NY 12180 [email protected] 2 Robert J. Graves, Decision Sciences and Engineering Systems Department, Rensselaer Polytechnic Institute, Troy, NY 12180 [email protected] 3 Charles J. Malmborg, Decision Sciences and Engineering Systems Department, Rensselaer Polytechnic Institute, Troy, N...

Rinat Nissim, PhD, Psychosocial Oncology and Palliative Care, Princess Margaret Hospital, University Health network, Toronto; Carmen G. Loiselle, PhD, Associate Professor, Faculty of Medicine, McGill University, and Senior investigator, Lady Davis Institute and Centre for nursing Research, Jewish General Hospital, Montreal; Doris Howell, PhD, RBC Chair Oncology nursing Research & Scientist, Psy...