Background and aims: Etokimab (an anti-IL-33 biologic) has been shown to significantly reduced the clinical severity of atopic dermatitis (AD) in a Phase 2A trial, suggesting an important role for IL-33 pathogenesis this disease. We recently showed that epidermal growth factor receptor (EGFR) dominates signaling keratinocytes from adults with lesions. The aim study was investigate possible EGFR...

1. Rajamani D, Thiel S, Vajda S, Camacho C. Anchor residues in protein-protein interactions. PNAS 2004;101(31):1128711292 2. Kussie, P. H.; Gorina, S.; Marechal, V.; Elenbaas, B.; Moreau, J.; Levine, A. J.; Pavletich, N. P. Science 1996, 274, 948-953. 3. Ding K, Lu Y, Nikolovska-Coleska Z, Wang G, Qiu S, Shangary S, Gao W, Qin D, Stuckey J, Krajewski K, Roller PP, Wang S. Structure-based design...

Thirteen red strains of Actinomadura (Nocardia) pelletieri and three of A. madurae were shown to produce prodigiosin-like pigments. Both of the two major pigments which were observed on thin-layer chromatograms had R(F) values significantly greater than prodigiosin. The main pigment from A. madurae 953 was shown by mass and nuclear magnetic resonance spectroscopies to be nonylprodigiosin. The m...

In this paper we propose a scalarization proximal point method to solve multiobjective unconstrained minimization problems with locally Lipschitz and quasiconvex vector functions. We prove, under natural assumptions, that the sequence generated by the method is well defined and converges globally to a Pareto-Clarke critical point. Our method may be seen as an extension, for the non convex case,...

2014 Dielectric measurements were performed in a large frequency range (10-4-10+5 Hz) on undoped cis-polyacetylene samples from several laboratories both with ohmic and blocking contacts. The carrier density is low (2 1016 cm-3) and constant but the mobility is thermally activated with a sample and contact dependent activation energy. A maximum activation energy of about 1.6 eV has been found w...

This paper studies the constrained multiobjective optimization problem of finding Pareto critical points of vector-valued functions. The proximal point method considered by Bonnel et al. (SIAM J. Optim., 4 (2005), pp. 953-970) is extended to locally Lipschitz functions in the finite dimensional multiobjective setting. To this end, a new approach for convergence analysis of the method is propose...

2014 A method systematically improving the annealed bounds (for the free energy and the ground state energy) is presented and illustrated by the example of disordered Ising models. An optimization procedure leads to new bounds for which the critical behaviour differs from the pure model behaviour. Geometrical effects, such as frustration, can also be included in this method. We obtain simple ex...

El presente trabajo examina una línea argumentativa de la historiografía moderna que tiende a desacreditar el valor histórico narrativa diodorea las guerras serviles sicilianas al concebir su autor se asemeja un novelista. Criticamos esa perspectiva analizando nociones diodoreas sobre verdad, franqueza y exactitud. Mostramos que, si bien Diodoro no interesa únicamente en verdad fáctica, ma...

The design principle of a biochemiluminescent instrument is presented. diagnoses influenza based on detection the flu viral neuraminidase activity. uses photomultiplier tube (PMT) as sensor, with 24 test channels. reaction disk driven by step motor to rotate, where reagent incubated. Finally, PMT detects number photons emitted and calculates enzyme correlation coefficient (R2) 2.83 5.06 log TCI...