Methyl 9-(1-methyl-1H-indol-3-yl)-9-oxononanoate was synthesized using Friedel–Crafts acylation between N-methyl indole and methyl 9-chloro-9-oxononanoate. The structure of the newly compound elucidated 1H-NMR, 13C-NMR, NOESY-1D, ESI-MS, FT-IR, UV-Vis spectroscopy.