CD4(+)CD25(hi) FOXP3(+) regulatory T cells (Tregs) maintain tolerance to self-Ags. Their defective function is involved in the pathogenesis of multiple sclerosis (MS), an inflammatory demyelinating disease of the CNS. However, the mechanisms of such defective function are poorly understood. Recently, we reported that stimulation of TLR2, which is preferentially expressed by human Tregs, reduces...

A total of 235 Active Galactic Nuclei (AGN) from two different soft X-ray surveys (the ROSAT Deep Survey –DRS– and the ROSAT International X-ray Optical Survey –RIXOS–) with redshifts between 0 and 3.5 are used to study the clustering of Xray selected AGN and its evolution. A 2 sigma significant detection of clustering of such objects is found on scales < 40 − 80 h Mpc in the RIXOS sample, whil...