Chloroform accumulation in the body and increase its steady-state concentrations blood of exposed people have been established to be associated with polymorphisms enzyme genes a genotype involved metabolism water disinfection byproducts (A415G EPHX1 gene, C1091T CYP2E1 zero mutations GSTT1 GSTM1 genes) (р < 0.000001). These correlate higher chloroform levels consuming chlorinated drinking wa...

Background: Infertility is a multifactorial disorder affecting one in ten couples, and in 50% of infertile couples, the male factor due to deteriorated semen quality is a major cause. In about 30% of infertile men seeking help for their problem, the etiology and pathogenesis are not yet known and their condition is considered idiopathic. Through animal studies conducted recently, hundreds of ge...

dna polymorphism within diacylglycerol transferase 2 (dgat2) / monoacyl glycerol transferases 2 (mogat2), leptin and butyrophilin genes were analysed using pcr-sscp in murrah buffalo. the single strand conformation polymorphism (sscp) analysis of amplified gene fragment in exon 5 of mogat2, exon 3 of leptin and intron 1 of butyrophilin gene revealed different patterns. a, b and c showed the fol...

Resistin (RETN), recently found to be relevant to inflammation and inflammatory disorders. We, therefore, aimed to investigate the potential role of RETN gene polymorphism in pathogenesis of acne vulgaris with familial history. We investigated the RETN-420C/G polymorphism in 180 patients with acne vulgaris and 180 healthy individuals in a case-control association analysis. In this study, we als...

Introduction: Amiodarone is one of drug with narrow therapeutics index. This medicine was metabolized by CYP3A4 and CYP2C8. The changes in the activity this enzymes CYP2C8 polymorphism will affect effect. study aimed to determine impact on amiodarone responses. Method: review article search PubMed keywords: ‘amiodarone’ ‘polymorphism CYP3A4’ CYP2C8’. Results: We collect 46 references Conclusion...

In this report, β-tubulin gene polymorphism was investigated in Haemonchus contortus  populations isolated from sheep flocks in different regions of Khouzestan province, southwestern Iran. The samples were chosen on the basis of regional variation in benzimidazole treatment background of sheep flocks. Our objective was to study the relationship between treatment background andβ -tubulin gene po...

Introduction: Considering the effectiveness of polymorphisms in the occurrence of respiratory diseases, it seems that these genetic variations in viral and microbial receptors can be effective in the occurrence and progression of the disease. The present study aimed to  assess the relationship between the C-159T polymorphism in the CD14 gene promoter and the severity of the disease in  Covid-19...

The Hindley/Milner polymorphic type system has been adopted in many programming languages because it provides the convenience of programming languages like Lisp along with the correctness guarantees that come with static type-checking. However, programming environments for such languages are still not as exible as those for Lisp. In particular, the style of incremental, top-down program develop...