Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular-matrix-associated protein that suppresses tumorigenicity or invasion in several model systems. We have identified, by in vitro footprinting, six AP-1 (activator protein-1) or AP-1-like binding sites in the mouse TIMP-3 promoter that bind purified c-Jun homodimers. Electrophoretic mobility shift assays revealed that the non-co...

Following human fascioliasis outbreaks in 1988 and 1999 in Gilan province, northern Iran, efforts are now made to shed light on the seasonal pattern of fascioliasis transmission in this endemic area, taking into account snail host populations, climatic conditions and human cases. Populations of the intermediate host snail (Lymnaea spp.) peak in May and November, while there is a fourfold increa...

Background:Ligneous conjunctivitis (LC) is a rare disease characterized by the development of wood-like pseudomembrane on tarsal conjunctiva secondary to type I plasminogen deficiency. Here we reported Chinese patient with LC in consanguineous family and performed literature review all mutations for this disease. Methods: A 13-month-old girl diagnosed her parents were included study. Hematoxyli...

The receptor for granulocyte colony-stimulating factor (G-CSF) can mediate differentiation and proliferation of hemopoietic cells. A proliferative signal is associated with activation of the ERK mitogen-activated protein kinase (MAPK) pathway. To determine whether other MAPK pathways are activated by G-CSF signalling, we have investigated activation of JNK/SAPK in cells proliferating in respons...

objective: rubella is a viral disease with minor morbidity, unless it is contracted by a pregnant woman in early pregnancy that leads to congenitalrubella syndromes. rubella occurrence during the first trimester leads to fetal death or severe congenital defects.present study was conducted to survey the protection level against rubella in the pregnant women of gilan in iran,to be used for the va...