n engl j med 369;8 nejm.org august 22, 2013 754 This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presente...

Word counts: 14 Abstract: 248 15 Introduction: 754 16 Discussion: 1745 17 Pages: 35 18 Figures: 6 black and white 19 20 * Corresponding author: 21 Shu-Ling Liang, Ph.D. 22 Department of Physiology and Pharmacology 23 Chang Gung University 24 259 Wen-Hwa 1st Road, Kwei-Shan, 25 Tao-Yuan, 33302, Taiwan 26 Phone: +886-3-2118800 ext. 3688 27 Fax: +886-3-2118700 28 E-mail: [email protected] 29 30

Numerical reproducibility failures appear in massively parallel floating-point computations. One way to guarantee the numerical reproducibility is to extend the IEEE-754 correct rounding to larger computing sequences, as for instance for the BLAS libraries. Is the overcost for numerical reproducibility acceptable in practice? We present solutions and experiments for the level 1 BLAS and we conc...

Fraction (10 bits) Sign (1 bit) Exponent (5 bits) 16-bit floating-point format defined in IEEE 754-2008 standard Storage support on most of the modern CPUs and GPUs Native computation support especially on mobile platforms (Up coming nVidia Pascal desktop GPUs are announced to have native computation support) Pros: Smaller cache footprint (compared to "regular" 32-bit floats) More energy effici...

The implementation of Taylor models arithmetic may use floating-point arithmetic to benefit from the speed of the floatingpoint implementation. The issue is then to take into account the roundoff errors. Here, we assume that the floating-point arithmetic is compliant with the IEEE-754 standard. We show how to get tight bounds of the roundoff errors, and more generally how to get high accuracy f...

Neural network simulations often spend a large proportion of their time computing exponential functions. Since the exponentiation routines of typical math libraries are rather slow, their replacement with a fast approximation can greatly reduce the overall computation time. This article describes how exponentiation can be approximated by manipulating the components of a standard (IEEE-754) floa...

a Reference Centre for Severe Pulmonary Hypertension, Department of Respiratory Medicine, AP-HP, Hôpital Bicêtre, INSERM U999, University Paris Sud, Le Kremlin-Bicêtre , b Department of Therapeutic Medicine, CHU Saint-Etienne, University of Saint-Etienne, Thrombosis Research Group, EA3065, Saint-Etienne , and c Hospices Civils de Lyon, Reference Center for Rare Pulmonary Diseases, Department of...

Amylin Pharmaceuticals, LLC. San Diego, CA 92121, USA 8 9 Running Head: Improved model and methods for characterizing NASH in mice 10 11 12 13 14 Both authors contributed equally. 15 *Corresponding Author: 16 Jason R. Clapper, PhD 17 Amylin Pharmaceuticals, LLC 18 9360 Towne Centre Drive 19 San Diego, CA 92121 20 Telephone: 858-754-4975 21 Fax: 858-642-7370 22 Email: [email protected] 23...

A theoretical structure that involves neutrino mass eigenstates at non relativistic as well as relativistic energies is presented. Using this framework, we find that if the particle X, with mass 33.9 MeV, of the KARMEN collaboration anomaly is identified with the third neutrino mass eigenstate, then the present limit of 23 MeV upper bound on the tau neutrino mass implies |Uτ3| < 0.82. Typeset u...