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Linkage analysis with restriction fragment length polymorphisms for the gene for type II procollagen (COL2A1) was carried out in a family with the Stickler syndrome, or arthro-ophthalmopathy, an autosomal dominant disorder that affects the eyes, ears, joints, and skeleton. The analysis demonstrated linkage of the disease and COL2A1 with a logarithm-of-odds score of 1.51 at zero recombination. A...
Delayed inflammatory and cell death responses are associated with reduced 1 pathogenicity in Lujo virus-infected cynomolgus macaques 2 3 Running title: Gene expression in Lujo and Lassa-infected macaques 4 5 Angela L. Rasmussen, Nicolas Tchitchek, David Safronetz, Victoria S. Carter, 6 Christopher M. Williams, Elaine Haddock, Marcus J. Korth, Heinz Feldmann, and 7 Michael G. Katze 3** 8 9 Depar...
A single nucleotide polymorphism (SNP) that causes a missense mutation of highly conserved Gln488 to His of the alpha isoform of the 90-kDa heat shock protein (Hsp90alpha) molecular chaperone is observed in Caucasians. The mutated Hsp90alpha severely reduced the growth of yeast cells. To investigate this molecular mechanism, we examined the domain-domain interactions of human Hsp90alpha by usin...
Carcinogenicity is one of the toxicological endpoints causing the highest concern. Also, the standard bioassays in rodents used to assess the carcinogenic potential of chemicals and drugs are extremely long, costly and require the sacrifice of large numbers of animals. For these reasons, we have attempted development of a global quantitative structure-activity relationship (QSAR) model using a ...
High-dimensional data are prevalent across many application areas, and generate an everincreasing demand for statistical methods of dimension reduction, such as cluster and significance analysis. One application area that has recently received much interest is the analysis of microarray gene expression data. The results of cluster analysis are open to subjective interpretation. To facilitate th...
In this paper, we propose a new Digital Sense Multiple Access with Delayed Transmission (DSMA/DT) protocol for reverse channel in high-speed wireless networks. The new protocol is motivated by the observation that the existing DSMA protocol does not yield satisfactory throughput for long round-trip propagation and processing delay, which occurs in outdoor, high-speed environments or when the re...
Systematic improvements in algorithmic design of regional ocean circulation models have led to significant enhancement in simulation ability across a wide range of space/time scales and marine system types. As an example, we briefly review the Regional Ocean Modeling System, a member of a general class of three-dimensional, free-surface, terrain-following numerical models. Noteworthy characteri...
This study investigates the association between institutional investors’ ownership and sell-side analysts’ stock recommendations in context of heterogeneous nature investors. Based on a sample 281 Malaysian public listed companies over period 2008–2013 (732 company-year observations), we find significant positive relationship ownership, particular held by privately managed investors recommendat...
PURPOSE To investigate the killing effect on OS cells of a combination of oxaliplatin and TRAIL and related molecular mechanisms. METHODS TRAIL and oxaliplatin were applied to OS732 cells singly or jointly and survival inhibition rates were measured by MTT assay, changes of cellular shape being assessed with inverted phase contrast and fluorescence microscopy. Apoptotic rates were analyzed by...
High Performance Medical Robot Requirements and Accuracy Analysis C. Mavroidis, J. Flanz, S. Dubowsky , P. Drouet and Michael Goitein 1 Department of Mechanical and Aerospace Engineering, Rutgers University 98 Brett Road, Room B-217, Piscataway, NJ 08854, USA Tel 732-445-0732, Fax 732-445-3124, email [email protected] 2 Northeast Proton Therapy Center, Massachusetts General Hospital Boston...
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