نتایج جستجو برای: 6r robot

تعداد نتایج: 108295  

Journal: :CoRR 2014
Zijia Li Josef Schicho

A closed 6R linkage is generically rigid. In this paper we give, for the first time, equational conditions on the Denavit/Hartenberg parameters that are necessary for mobility. The conditions suggest to distinguish the movable 6R linkages into various types characterized by their bond diagrams.

Journal: :Chemical & pharmaceutical bulletin 2010
Katsuyoshi Matsunami Hideaki Otsuka Yoshio Takeda

The absolute stereochemistry of blumenol C glucoside and byzantionoside B was revised here as (6R,9S)- and (6R,9R)-9-hydroxymegastigman-4-en-3-one 9-O-beta-D-glucopyranosides, respectively, by modified Mosher's method. The empirical rules of (13)C-NMR chemical shift to determine the absolute stereochemistry of C-9 of 9-hydroxymegastigmane 9-O-beta-D-glucopyranoside were also discussed.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1996
I Walev P Vollmer M Palmer S Bhakdi S Rose-John

Cleavage of membrane-associated proteins with the release of biologically active macromolecules is an emerging theme in biology. However, little is known about the nature and regulation of the involved proteases or about the physiological inducers of the shedding process. We here report that rapid and massive shedding of the interleukin 6 receptor (IL-6R) and the lipopolysaccharide receptor (CD...

2017
Wei Feng Hongrui Liu Tingting Luo Di Liu Juan Du Jing Sun Wei Wang Xiuchun Han Kaiyun Yang Jie Guo Norio Amizuka Minqi Li

Interleukin (IL)-6 is known to indirectly enhance osteoclast formation by promoting receptor activator of nuclear factor kappa-B ligand (RANKL) production by osteoblastic/stromal cells. However, little is known about the direct effect of IL-6 on osteoclastogenesis. Here, we determined the direct effects of IL-6 and its soluble receptor (sIL-6R) on RANKL-induced osteoclast formation by osteoclas...

Journal: :Mediators of Inflammation 1997
I. Drucker A. Klajman M. Revel Y. Manor S. Ben-Efraim D. Novick

Interleukin-6 (IL-6) and soluble interleukin-6 receptor (sIL-6R) were detected in supernatants of cultures of B chronic lymphatic leukaemia (CLL) lymphocytes. Phorbol-12-myristate 13 acetate (PMA) caused a decrease in the levels of IL-6 in 14 out of 16 cultures and an increase in levels of sIL6R in all 15 cases. The effect of pokeweed mitogen (PWM) was variable and not significant. The levels o...

Journal: :Journal of immunology 2002
Suzanne M Hurst Rachel M McLoughlin James Monslow Sara Owens Llinos Morgan Gerald M Fuller Nicholas Topley Simon A Jones

Recently, we identified that regulation of leukocyte recruitment by IL-6 requires shedding of the IL-6R from infiltrating neutrophils. In this study, experiments have examined whether other IL-6-related cytokines possess similar properties. Levels of oncostatin M (OSM) and leukemia inhibitory factor were analyzed in patients with overt bacterial peritonitis during the first 5 days of infection....

2016
Christophe Blanchetot Natalie De Jonge Aline Desmyter Nico Ongenae Erik Hofman Alex Klarenbeek Ava Sadi Anna Hultberg Anke Kretz-Rommel Silvia Spinelli Remy Loris Christian Cambillau Hans de Haard

Interleukin 6 plays a key role in mediating inflammatory reactions in autoimmune diseases and cancer, where it is also involved in metastasis and tissue invasion. Neutralizing antibodies against IL-6 and its receptor have been approved for therapeutic intervention or are in advanced stages of clinical development. Here we describe the crystal structures of the complexes of IL-6 with two Fabs de...

2017
Grazia Carbotti Amin Reza Nikpoor Paola Vacca Rosaria Gangemi Chiara Giordano Francesco Campelli Silvano Ferrini Marina Fabbi

BACKGROUND Recently, immunotherapy with anti-PD-1 antibodies has shown clinical benefit in recurrent Small Cell Lung Cancer (SCLC). Since anti-PD-1 re-activates anti-tumor Cytotoxic T Lymphocyte (CTL) responses, it is crucial to understand the mechanisms regulating HLA class I, and PD-L1 expression in HLA-negative SCLC. Here we addressed the role of IL-27, a cytokine related to both IL-6 and IL...

2008
Hai Huang Hao Wang Nan Qi R. Stephen Lloyd Carmelo J. Rizzo Michael P. Stone

The trans-4-hydroxynonenal (HNE)-derived exocyclic 1, N(2)-dG adduct with (6S,8R,11S) stereochemistry forms interstrand N(2)-dG-N(2)-dG cross-links in the 5'-CpG-3' DNA sequence context, but the corresponding adduct possessing (6R,8S,11R) stereochemistry does not. Both exist primarily as diastereomeric cyclic hemiacetals when placed into duplex DNA [Huang, H., Wang, H., Qi, N., Kozekova, A., Ri...

Journal: :Blood 1996
Y H Chen P Desai R T Shiao D Lavelle A Haleem J Chen

Interleukin-6 (IL-6)/IL-6 receptor (IL-6R) plays a major role in autocrine/paracrine growth regulation of myeloma cells. We investigated the effect of dexamethasone and all-trans retinoic acid, previously shown to modulate IL-6/IL-6R, on the in vitro growth of a human myeloma cell line, OPM-2. Both agents inhibited the clonogenic growth and 3H-thymidine incorporation in a concentration-dependen...

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