β-site amyloid precursor protein cleaving enzyme (BACE-1) is a validated target for Alzheimer therapy due to its distinctive role in pathogenesis of AD. In the present contribution, a series of new 3,5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridine structures were synthesized as BACE-1 inhibitors (6a-6n). In vitro BACE-1 inhibitory activities were determined by enzymatic fluoresce...

The classical approach to the problem of placing n copies of a search model in the asymmetric unit of a target crystal structure is to divide this 6n-dimensional optimization problem into a succession of three-dimensional searches (rotation-function followed by translation-function searches for each of the models). Here, it is shown that a structure-determination method based on a reverse Monte...

Introduction Manganese-enhanced MRI (MEMRI) is an increasingly used imaging method in animal research, which allows improved T1-weighted tissue contrast, thus enabling in vivo visualization of neuronal activity . At higher concentrations, however, manganese (Mn) exhibits toxic effects that interfere with the animals’ behaviour and well-being. While CD1 mice tolerate single doses of ~100mg/kg Mn...

METHODOLOGY AND PRINCIPAL FINDINGS Oleuropein promoted cultured human follicle dermal papilla cell proliferation and induced LEF1 and Cyc-D1 mRNA expression and β-catenin protein expression in dermal papilla cells. Nuclear accumulation of β-catenin in dermal papilla cells was observed after oleuropein treatment. Topical application of oleuropein (0.4 mg/mouse/day) to C57BL/6N mice accelerated t...

We investigated the response to challenge infection with Cryptosporidium parvum oocysts in immunosuppressed C57BL/6N mice. In the primary infection, fecal oocyst shedding and parasite colonization were greater in immunosuppressed mice than in nonimmunosuppressed mice. Compared with primary infection, challenge infection with C. parvum didn't show any oocyst shedding and parasite colonization. E...

For a given graph $H$, the Ramsey number $r(H)$ is minimum $N$ such that any 2-edge-coloring of complete $K_N$ yields monochromatic copy $H$. Given positive integer $n$, \emph{fan }$F_n$ formed by $n$ triangles share one common vertex. We show ${9n}/{2}-5\le r(F_n)\le {11n}/{2} + 6$ for $n$. This improves previous best bounds $r(F_n) \le 6n$ Lin and Li \ge 4n+2$ Zhang, Broersma Chen.