The protein tyrosine phosphatases (PTPs) IA-2 and phogrin (IA-2beta) are major autoantigens in type 1 diabetes that possess common serological epitopes in their COOH termini. The epitopes recognized by the T-cells that cause the disease, however, remain to be defined. Eight phogrin-specific T-cell clones were generated from NOD mice, and their epitopes were mapped. The mapping was performed ini...

I N T R O D U C T I O N It is generally accepted that glial cells provide mechanical and, perhaps, metabol ic support for the neuronal cells that they surround but do not par t ic ipate directly in the events of excitabil i ty (Nakai, 1963; Kuff ler and Nicholls, 1966). However, in 1976 Villegas et al. (1976) reported electrophysiological evidence for the existence of sodium channels in Schwann...

I N T R O D U C T I O N I n v e r t e b r a t e r o d p h o t o r e c e p t o r s b i o c h e m i c a l m a c h i n e r y f o r exc i t a t i on a n d a d a p t a t i o n is c o n t a i n e d w i th in t he o u t e r s e g m e n t , a c y l i n d r i c a l o r g a n e l l e w h i c h J. GEN. PHYSIOL. ~) The Rockefeller University Press 00"22-1295/79/05/062912551.00 629 Volume 73 May 1979 629-65...

This paper is a continuation of our previous works where we study maps from $$X_0(N)$$ , $$N\ge 1$$ into $${\mathbb {P}}^2$$ constructed via modular forms the same weight and criteria that such map birational (see Muic in Monatsh Math 180(3):607–629, 2016). In present paper, approach based on theory primitive elements finite separable field extensions. We prove most cases are birational. con...

Manganese Superoxide Dismutase (MnSOD) expression has been found to be low in human pancreatic ductal adenocarcinoma (PDAC). Previously, we have reported that microRNA-301a (miR-301a) was found being upregulated via nuclear factor-κB (NF-κB) feedback loop in human PDAC. In this study, we investigate whether the miR-301a expression level is associated with MnSOD expression in human PDAC. We esta...

Promoting employee voice behavior is important for the sustainable development of organizations. Drawing on conservation resources theory, study examined association between emotional labor and mediation work engagement in this relationship. Surveys were collected at two time points, four weeks apart, from 629 employees service industry China. The results show that surface acting negatively rel...

Several matrix metalloproteinases (MMPs) are hypothesized to play key roles in the wound healing process due, their ability break down various extracellular components. Expression levels of MMPs, or inhibitors, may be useful for predicting risk non-healing. However, methods used collect human fluid diverse with little evidence rigorous method validation literature. Therefore, we aimed develop a...

The DermTech Pigmented Lesion Assay (PLA) is a qPCR-based assay that aids in the detection of melanoma by assessing up-regulation two melanoma-associated genes, LINC00518 and PRAME, skin samples collected non-invasive adhesive patches. This study to establish performance characteristics PLA post optimization, investigate prognostic potential comparison qPCR amplification cycle positive with his...