Carcinogenic arsenic, nickel, and chromium compounds induced morphological and neoplastic transformation but no mutation to ouabain resistance in 10T1/2 mouse embryo cells; lead chromate also did not induce mutation to ouabain or 6-thioguanine resistance in Chinese hamster ovary cells. The mechanism of metal-induced morphological transformation was likely not due to the specific base substituti...

The metabolism of 9-butyl thioguanine (9-BTG)1 was studied in normal tissues and the Ehrlich ascites tumor with and without pretreatment with azaserine. The study of the distribution and metabolism of the drug was facilitated by the synthesis of 9-butyl-6-thioguanine-8-C14. The results showed that 9-BTG was rapidly cleared from the blood, rapidly catabolized, and that the metabolites were rapid...