interest in hydroxy - carboxylic acid 2 (hca2) receptor has been raised since it is the target of antidyslipidemic drug nicotinic acid. the present study aimed to evaluate the presence of mrna of this receptor in different organs of laboratory rat. twenty two different organs of rats including mesenteric fat, epididymis (head, body and tail), testis, ovary, xiphoid process, liver, adrenal gland...

The condensation of substituted pyrazine-2-carboxylic acid chlorides with ring-substituted anilines yielded five substituted pyrazine-2-carboxylic acid amides. Thesynthesis, and analytical, lipophilicity and biological data of the newly synthesizedcompounds are presented in this paper. The photosynthesis inhibition, antialgal activityand the effect of a series of pyrazine derivatives as abiotic...

Although studies on the degradative metabolism of hydroxyproline have revealed that this amino acid is converted at least in part to glutamic acid (I-G), knowledge of the intermediates in this conversion and of other products of hydroxyproline metabolism is not yet complete. In the course of experiments on the metabolism of hydroxyproline, it was observed that incubation of hydroxyproline with ...

The title racemate, C(11)H(14)O(3), aggregates in the crystal structure as acid-to-ketone O-H⋯O hydrogen-bonding catemers whose components are glide-related. The relative stereochemistry at the carboxyl group arises spontaneously during the synthesis. Two inter-molecular C-H⋯O=C close contacts were found, both involving the acid group.

Binding of the coagonist glycine to the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors is potently antagonized by 2-carboxy-4-hydroxyquinolines. We show that closely related derivatives, 4-hydroxy-quinolines and 4-hydroxquinoline-3-carboxylic acids, antagonize the agonist response of the recombinant inhibitory glycine receptor (GlyR). In Xenopus laevis oocytes expressing the GlyR al...

In the title racemic compound, C(11)H(16)O(3), the mol-ecule adopts a conformation that places its carboxyl group in an equatorial position. Mol-ecules aggregate by hydrogen-bond pairing of carboxyl groups, yielding centrosymmetric dimers that are arranged into layers in the (020) planes.

In the title compound, C(12)H(14)N(2)O(2), the benzene ring and imidazole ring are almost coplanar, making a dihedral angle of 2.47 (14)°. Inter-molecular O-H⋯N, N-H⋯O and C-H⋯O hydrogen bonds stabilize the crystal structure.

Phytochemical investigations of the ethanolic extract of the seeds of Rhus coriaria L. (Anacardiaceae) led to the identification of four new xanthones, characterized as 2,3-dihydroxy-7-methyl xanthone (1), 2,3,6-trihydroxy-7-hydroxymethylene xanthone-1-carboxylic acid (2), 2-methoxy-4-hydroxy-7-methyl-3-O-beta-D-glucopyranosyl xanthone-1,8-dicarboxylic acid (4), and 2-hydroxy-7-hydroxymethylene...

Molecular structure, tautomeric forms, vibrational modes, optic and electronic properties of 6-Aza-2-thiouracil-5-carboxylic acid (6A2T5CA) molecule were characterized by FT-IR, Raman, UV-VIS spectral methods DFT method. The experimental results Show that FT-IR Raman spectroscopic could be used to determine the different forms 6A2T5CA clearly. Although title has such as oxo hydroxy because inte...

Interest in hydroxy - carboxylic acid 2 (HCA2) receptor has been raised since it is the target of antidyslipidemic drug nicotinic acid. The present study aimed to evaluate the presence of mRNA of this receptor in different organs of laboratory rat. Twenty two different organs of rats including mesenteric fat, epididymis (head, body and tail), testis, ovary, xiphoid process, liver, adrenal gland...