Adenovirus type 12 was inoculated intraperitoneally into newborn hamsters. At selected periods, the soft peritoneal tissues were excised and transplanted subcutaneously into 16to 29-day-old hamsters. With the tissues taken at 6 hours or more after the virus inoculation, tumors developed at the transplanted site. The period from virus inoculation to excision and transplantation of the soft perit...

Young mice fed diets deficient in pyridoxine or fed desoxypyridoxine after the inoculation of the pneumonia virus of mice were more resistant to infection than well nourished controls. The susceptibility of young mice to PVM increased with the duration of pyridoxine administration after inoculation. Dietary protein restriction when pyridoxine was provided did not affect the susceptibility of mi...

Observations on the therapeutic effect of penicillin in both experimental and clinical leptospirosis have not been in full agreement. Heilman and Herrel (1) reported that of 32 guinea pigs which, 17 to 24 hours after the inoculation with L. icterohaemorrhagiae, received a total of 800 oxford units (hereafter abbreviated as o.u.) of penicillin daily for 7 days, 23 showed a complete suppression o...

Infectivity and pathogenicity of Bordetella bronchiseptica to rabbits were investigated by intranasal inoculation of the organism to suckling and young animals. Results are summarized as follows. 1. By inoculation of 5 X 10(4) and 10(6) organisms, the infection developed in 60% and 100% of young rabbits, respectively. 2. In young rabbits, the growth of the organism was evident in the trachea wi...

The antitumor activities of forphenicinol against murine transplantable tumors were examined. Ehrlich carcinoma was suppressed by treatment with 0.08 approximately 0.31 mg/kg/day of forphenicinol given for 10 days starting 5 days after tumor inoculation. IMC carcinoma was also suppressed by treatment with 0.5 approximately 5 mg/kg/day given for 5 days starting 8 days after the inoculation. The ...

Thrombocytopenia is a frequent complication of acute leukemias of humans and animals. To define the possible causes of this decrease in platelets, we have studied platelet kinetics in mice after transplantation of 10(6) ascites cells from mice bearing L1210 leukemia. The circulating half-time of 51Cr-labeled platelets was reduced to approximately one-half that of controls when studied 1 or 3 da...