The studies reported herein demonstrate the efficacy of alpha-particle-targeted radiation therapy of peritoneal disease with Herceptin as the targeting vehicle. Using the CHX-A-DTPA linker, Herceptin was radiolabeled with indium-111 and bismuth-213 with high efficiency without compromising immunoreactivity. A pilot radioimmunotherapy study treating mice bearing 5-day LS-174T (i.p.) xenografts, ...

The effect of hydrogen peroxide (H2O2) on root-knot nematode (RKN, Meloidogyne javanica) in tomato was investigated. Soil drenching with exogenous H2O2 was done using seven H2O2 concentrations (1, 10, 100, 250, 500, 750 and 1 000 mM) at different application times (24 hours before the time of plant inoculation with the RKN (T1), at the time of inoculation (T2), and 24 hours after the inoculatio...

BACKGROUND & OBJECTIVES Artemisinin isolated from Artemisia annua is the most potent antimalarial drug against chloroquine-resistant Plasmodium falciparum malaria. Artemisia vulgaris, an invasive weed, is the only Artemisia species available in Sri Lanka. A pilot study was undertaken to investigate the antiparasitic activity of an A. vulgaris ethanolic leaf extract (AVELE) in a P. berghei ANKA ...

In this study, we evaluated the protective activity of aqueous extract of jaggery against CCl4-induced hepatic-renal damage in rats. Jaggery was administered in one group at doses of 250, 500 and 750 mg/ kg body weight (bwt) (p.o., once only), and CCL4 was administered in another group at a dose of 1.5 ml/kg bwt (i.p., once only) to evaluate the protective effect of jaggery on induced oxidative...

OBJECTIVE To assess cochlear trauma during cochlear implantation by electrocochleography (ECoG) and cone beam computed tomography (CBCT) and to correlate intraoperative cochlear trauma with postoperative loss of residual hearing. METHODS ECoG recordings to tone bursts at 250, 500, 750, and 1000 Hz and click stimuli were recorded before and after insertion of the cochlear implant electrode arr...

Bi 4 Ge 3 O 12 (bismuth germanate – BGO) single crystals were produced by the Czochralski technique and their electrical and dielectric properties were investigated by impedance spectroscopy. The isothermal ac measurements were performed for temperatures from room temperature up to 750 °C, but only the data taken above 500 °C presented a complete semicircle in the complex impedance diagrams. Ex...

This study included 6,971 students in grades 9 and 10 (ages 13 to 16 years) from 158 schools who participated in the 2009/2010 Health Behaviour in School-aged Children Study. Students provided information on where they typically ate lunch. The number of food retailers was obtained for six road network buffer sizes (500, 750, 1,000, 1,500, 2,000, and 5,000 meters) surrounding schools. Associatio...

OBJECTIVE The present study was to investigate the antiasthmatic potential from the flavonoid fraction of Apium leptophyllum fruit (FFALF) to validate its traditional claim. MATERIALS AND METHODS The antiasthmatic activity of FFALF was evaluated by histamine or acetylcholine-induced bronchospasm model in guinea pigs, compound 48/80 induced mast cell degranulation in albino rats and histamine-...