In the early 1970s, Congress directed the Secretary of Health, Education and Welfare to create a commission for the purpose of ascertaining the important principles that should guide biomedical research that uses human research subjects. The report of this commission was to be published by the Secretary in the Federal Register and, unless the Secretary made any other proposals, it was to become...

Pharmaceutical production and distribution constitute big business. For the companies the rewards can be substantial. Rates of return on drug company investments tend to be higher than many other manufacturing enterprises. But reward is only one side of the story. There is also the issue of social risk, the focus of this article. Social risk for pharmaceutical production is especially pronounce...

ISSN: 1526-5161 (Print) 1536-0075 (Online) Journal homepage: http://www.tandfonline.com/loi/uajb20 Why Academic Medical Centers Should Ban Drug Company Gifts to Individuals Carson Strong To cite this article: Carson Strong (2010) Why Academic Medical Centers Should Ban Drug Company Gifts to Individuals, The American Journal of Bioethics, 10:1, 13-15 To link to this article: http://dx.doi.org/10...

If a drug company wanted to create the ideal cholesterol-lowering medication, here's what it would make: a safe, inexpensive pill that lowered levels of LDL (bad) cholesterol and triglycerides, raised HDL (good) cholesterol, and changed the sizes of cholesterol particles to make them less harmful or more beneficial. Of the current cholesterol-lowering drugs on the market, niacin comes closest t...

Studies of drug treatments are more likely to report favourable outcomes when they are funded by the pharmaceutical industry. We compared drug trials reported in three major psychiatric journals to investigate these influences. Independent studies were more likely to report negative findings than industry-funded studies. However, the involvement of a drug company employee had a much greater eff...

This paper examines the performance of the Morningstar Solvency Score, Morningstar's new accounting-ratio based metric for predicting bankruptcy, in comparison to the Altman Z-Score and Distance to Default models. Specifically we tested the following: 1. The ordinal ability of each model to distinguish companies most likely to file for bankruptcy from those least likely to file for bankruptcy a...

We compared four doses of amphotericin B lipid complex (ABLC) with three doses of fluconazole in temporarily neutropenic mice in a murine model of disseminated candidiasis due to four different isolates of Candida tropicalis. The mice were infected with a 90% lethal dose of four strains of C. tropicalis for which the fluconazole MICs ranged from 1 to >125 mg/liter 3 days after receiving 200 mg ...

P lanta de Regasificacion de Sagunto, S.A (Saggas) is constructing a new LNG receiving facility in Sagunto, 50 km north of Valencia (Spain), with a capacity of 3 million tpy of LNG, to be supplied from Egypt through a project initially promoted by Union Fenosa. Saggas is owned by three major electric companies in Spain: Union Fenosa (50%), Iberdrola (30%) and Endesa (20%). Saggas will be in cha...

Introduction Biotherapeutics emerged in the 1970s as viable alternatives to small molecule drugs when the advent of recombinant DNA technology allowed for cost-efficient, large-scale manufacture of proteins in cultured cells under controlled conditions. In 1982, recombinant human insulin, developed by Genentech and Eli Lilly, was the first biotechnology therapy to be approved by the FDA. Since ...

When an experimental medicine helping her son was dropped because it didn’t seem profitable, Connecticut homemaker Abbey Meyers turned into a lobbyist. Her crusade: Change the law to create incentives to develop drugs for rare diseases. Congress responded with the Orphan Drug Act of 1983, giving companies a seven-year monopoly for bringing a new treatment for a rare disease to market. Within tw...