نتایج جستجو برای: 5 fluorouracil colon cancer

تعداد نتایج: 2083830  

Journal: :Journal of Crohn's & colitis 2012
Antonio Tursi

A 48-year-old male underwent to colonoscopy due to an 8-month history of abdominal pain, iron-deficiency anemia and weight loss. Erythro-sedimentation rate and C-reactive protein were increased, and searching for fecal occult blood test was positive. Colonoscopy showed a stenosing neoplastic lesion involving the ascending colon (Fig. 1a); at the same time, diffuse diverticulosis was found in de...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2003
W Scheithauer J McKendrick S Begbie M Borner W I Burns H A Burris J Cassidy D Jodrell P Koralewski E L Levine N Marschner J Maroun P Garcia-Alfonso J Tujakowski G Van Hazel A Wong J Zaluski C Twelves

BACKGROUND Oral capecitabine achieves a superior response rate with an improved safety profile compared with bolus 5-fluorouracil-leucovorin (5-FU/LV) as first-line treatment for patients with metastatic colorectal cancer. We report here the results of a large phase III trial investigating adjuvant oral capecitabine compared with 5-FU/LV (Mayo Clinic regimen) in Dukes' C colon cancer. PATIENT...

Journal: :International Journal of Cancer 2021

Lipocalin 2 is a siderophore-binding protein that regulates iron homeostasis. expression elevated in multiple tumor types; however, the mechanisms drive progression upon remain unclear. When over-expressed, it leads to resistance 5-fluorouracil colon cancer cell lines vitro and vivo by inhibiting ferroptosis. inhibits ferroptosis decreasing intracellular levels stimulating of glutathione peroxi...

2017
Jiankai Wang Wenjuan Wang Hongyi Cai Binbin Du Lijuan Zhang Wen Ma Yongguo Hu Shifang Feng Guoying Miao

With regards to colon cancer, resistance to 5‑fluorouracil (5‑FU)‑based chemotherapy and cancer stem cells (CSCs) are considered important factors underlying therapy failure. Metastasis‑associated colon cancer 1 (MACC1) has been associated with poor prognosis and the promotion of metastasis within several types of cancer. However, the biological behavior of MACC1 in chemoresistance and CSC‑like...

2013
Taek-Gu Lee Sang-Jeon Lee

Subcutaneous metastasis from colorectal cancer is an unusual presentation. Most perineal subcutaneous metastases are found in extensive involvements of multiorgan metastases or local recurrences of rectal cancer. Subcutaneous metastasis from colon cancer is considered as a distant metastasis with poor prognosis. We report an unusual case of solitary subcutaneous metastasis beneath the perineum ...

2010
Sabine Tejpar Monica Bertagnolli Fred Bosman Heinz-Joseph Lenz Levi Garraway Frederic Waldman Robert Warren Andrea Bild Denise Collins-Brennan Hejin Hahn D. Paul Harkin Richard Kennedy Mohammad Ilyas Hans Morreau Vitali Proutski Charles Swanton Ian Tomlinson Mauro Delorenzi Roberto Fiocca Eric Van Cutsem Arnaud Roth

The number of agents that are potentially effective in the adjuvant treatment of locally advanced resectable colon cancer is increasing. Consequently, it is important to ascertain which subgroups of patients will benefit from a specific treatment. Despite more than two decades of research into the molecular genetics of colon cancer, there is a lack of prognostic and predictive molecular biomark...

Journal: :International journal of oncology 2014
Rui Zhang Kyoung Ah Kang Mei Jing Piao Ki Cheon Kim Jian Zheng Cheng Wen Yao Ji Won Cha Young Hee Maeng Weon Young Chang Pyong-Gon Moon Moon-Chang Baek Jin Won Hyun

Glutathione S-transferase π-1 (GSTP-1) is a member of the glutathione S-transferase enzyme superfamily, which catalyzes the conjugation of electrophiles to glutathione during the process of detoxification. In this study, the epigenetic alterations of GSTP-1 expression in human colorectal cancers and the underlying mechanisms were investigated. In 10 colon cancer patients, proteomic analysis rev...

Journal: :Anticancer research 2006
Kiyoko Kawamura Nobuhiro Takiguchi Akihiko Wada Hisanori Takenobu Hideki Kimura Hiroaki Soda Matsuo Nagata Takehide Asano Masatoshi Tagawa

Uridine phosphorylase (UP) is one of the enzymes involved in 5-fluorouracil (5-FU) activation. The expression was compared in paired specimens from cancerous and non-cancerous regions of gastric, colon and lung cancer patients. Among 28 paired gastric samples, 20 cases showed greater expression in tumors than in normal surrounding tissues and 8 cases showed equal or lower expression levels in t...

Background and purpose: Colorectal cancer ( CRC ) is highly prevalent and conventional therapies are associated with side effects, therefore, application of novel complementary treatment such as probiotics (especially Saccharomyces cerevisiae) is necessary. The aim of this study was to investigate the effect of heat-killed form of S.cerevisiae on growing rate and apoptosis (expression levels of...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2003
F Di Costanzo A Sobrero S Gasperoni L Dogliotti L Frassineti A Falcone R Lionetto P Bruzzi G Luppi L Gallo P Conte A Comandone D Turci M Marzola U Folco E Pfanner M Mestriner C Boni C Galli M Tonato R Rosso

BACKGROUND To determine whether the addition of leucovorin to the combination 5-fluorouracil plus levamisole prolongs disease-free survival and overall survival in patients with radically resected colon cancer (Dukes' B(2-3) and C). PATIENTS AND METHODS Patients (1703) were accrued between March 1992 and February 1995 in a large-scale clinical trial within five Italian cooperative groups. Aft...

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