The Drosophila transforming growth factor beta (TGF-beta) homolog Decapentaplegic (Dpp) acts as a morphogen that forms a long-range concentration gradient to direct the anteroposterior patterning of the wing. Both planar transcytosis initiated by Dynamin-mediated endocytosis and extracellular diffusion have been proposed for Dpp movement across cells. In this work, we found that Dpp is mainly e...

Determinantal point process (DPP) is an important probabilistic model that has extensive applications in artificial intelligence. The exact sampling algorithm of DPP requires the full eigenvalue decomposition of the kernel matrix which has high time and space complexities. This prohibits the applications of DPP from large-scale datasets. Previous work has applied the Nyström method to speedup t...

Twelve genotypes of bread wheat, with four levels nitrogen (0, 75, 150, 225 kg N ha-1). were grown in split block design three replication growing season (2021), correlation, phenotypic and genotypic coefficient variation, heritability genetic advance estimated for (days 75% flowering, plant height, grain filling, yield, number spike/plant, spike length, weight, flag leaf area, biomes, protein ...

OBJECTIVES This retrospective analysis was done in type 2 diabetes patients to study whether treatment with either sitagliptin or other Dipeptidyl peptidase-4 (DPP-4) inhibitors increased the risk of pancreatitis. Comparison with patients treated with other Oral Antidiabetic Drugs (OADs) was done. METHODS Asian Indian type 2 diabetic subjects (duration > or = 5 years) treated with sitagliptin...

Dentin phosphoprotein (phosphophoryn, DPP) is a unique acidic protein in dentin. Except for type I collagen, DPP is the most abundant extracellular matrix protein in dentin. This protein is characterized by high contents of phosphoserine (45-50%) and aspartic acid (35-38%) (Butler et al., 1995)1). Because of the high levels of aspartic acid and phosphoserine, this protein has polyanionic charac...

HYPOTHESIS Dipeptidyl aminopeptidase IV (DPP IV) activity in cytological samples from a follicular thyroid tumor is the most sensitive and specific indicator for the detection of follicular carcinoma of the thyroid gland. Dipeptidyl aminopeptidase IV activity is independent of cytological characteristics and superior to other clinical findings. DESIGN AND PATIENT SELECTION: Among the patients s...

Pretransplantation panel reactive antibody (PRA) testing assesses posttransplantation risk for antibody-mediated graft injury. It was postulated analogously that screening for effector/memory alloreactive T cells by "panel of reactive T cells" (PRT) using IFN-gamma enzyme-linked immunosorbent spot assays would evaluate independently cellular alloimmunity in transplant candidates. Peripheral blo...

W hen will it be done? " Senior managers will ask their software project managers this question more than 250,000 times this year. Corporations, which collectively commit over US$300 billion annually toward new software project initiatives, 1 will want to know the answer. However, when you consider Barry Boehm's claim that early software life-cycle estimates vary by a factor of four (25 to 400 ...

BACKGROUND In a cross-sectional study we studied the fasting serum DPP-4 enzymatic activity (sDPP-4) and the insulin resistance index (HOMA2-IR) in gliptin naïve patients with type 2 diabetes and in non-alcoholic fatty liver disease (NAFLD) and in healthy controls (CNTRL). METHODS AND FINDINGS sDPP-4 was measured by kinetic assay in 39 NAFLD (F/M:19/20, mean age: 47.42 yrs) and 82 type 2 diab...

BACKGROUND The Diabetes Prevention Program (DPP) study showed that weight loss in high-risk adults lowered diabetes incidence and cardiovascular disease risk. No prior analyses have aggregated weight and cardiometabolic risk factor changes observed in studies implementing DPP interventions in nonresearch settings in the United States. METHODS AND FINDINGS In this systematic review and meta-an...