BACKGROUND & AIMS Activation of NF-kappaB/Rel has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Various drugs used in the treatment of IBD, such as glucocorticoids, 5-aminosalicylic acid, and sulfasalazine, interfere with NF-kappaB/Rel signaling. The aim of this study was to define the molecular mechanism by which sulfasalazine inhibits NF-kappaB activation. METHODS...

ABBREVIATIONS: μmMicrometer, nmNanometer, PMMA Poly (methylmethacrylate), PACA Poly (alkylcyanoacrylate), PMM Poly (methylidenemalonate), SME Sub-micron emulsion, PAMAM Polyamido amines, 5-ASA 5-Aminosalicylic acid, McMolar mass of the core, MmMolar mass of the branched monomer, MtMolar mass of the terminal groups, ncCore multiplicity, nmBranch-juncture multiplicity, GGeneration number, CMCCrit...

Background: The protective effect of the chloroform extract of Cyperus rotundus (CHCR) is attributed to its anti-inflammatory and antioxidant activities. Cytokines, important regulators of inflammation and repair, play a key role in the pathogenesis of inflammatory bowel disease (IBD). Targeting these cytokines can effectively ameliorate the symptoms of IBD. The aim of the present study was to ...

INTRODUCTION Oral formulations of 5-aminosalicylic acid (5-ASA) for treatment of ulcerative colitis have been developed to minimize absorption prior to the drug reaching the colon. In this study, we investigate the release of 5-ASA from available oral mesalamine formulations in physiologically relevant pH conditions. METHODS Release of 5-ASA from 6 mesalamine formulations (APRISO®, Salix Phar...