Benign prostatic hyperplasia (BPH) is the most common condition in aging men, associated with lower urinary tract symptoms. It is caused due to the augmented levels of the androgen dihydrotestosterone. Dutasteride, a 5α-Reductase inhibitor has been recommended for the treatment of BPH upon oral administration. However, long term oral administration of dutasteride may cause sexual problem in man...

The hair follicle (HF) undergoes cycles of growth (anagen), regression (catagen) and rest (telogen) phases. Both chronic reactive loss are linked to a dysfunction the HF cycle leading premature loss. Therefore, use specific active ingredients targeting could improve aim this study was evaluate efficacy 3 on anchorage in dermal papilla cells isolated from human (DPC): new patented extract Silybu...

Background Skeletal muscle mass and function are partly maintained by the supply of amino acids, altered acid transport is an important cause frailty that can lead to decreased independence with increasing age slow trauma recovery. The system-A sodium coupled neutral transporter (SNAT)-2 coded gene family SLC38A2 generates a 506 56 kDa protein acids in skeletal muscle. Ageing associated decreas...

Objective(s): Kisspeptin and opioids are important factors for controlling GnRH/LH secretion. In present study, influences of kisspeptin or morphine were investigated on 5α- reductase or aromatase (CYP19) genes expression in the hypothalamus, testis and liver. It aimed to investigate whether kisspeptin pathway may control morphine effects on plasma concentration of tes...

BACKGROUND 5α-reductase activity might be important during the development of polycystic ovary syndrome (PCOS). However, the changes of 5α-reductase activity in PCOS subjects and the relationship between 5α-reductase activity and body mass index (BMI), insulin resistance (IR) remain largely unknown. METHODS We performed a meta-analysis to examine 5α-reductase activity in women with PCOS; expl...

one of the mechanisms involved in the regulation of the immune system by steroid hormones could be the monocytic-macrophage system. in this study the effect of the male hormone 5a-dht on cytokine release by peritoneal macrophages (mφ) of male and female nzb/balbc mice was investigated. macrophages from male mice activated with lps produced a greater amount of il-1β (21.8%) (p<0.05) and il-6 (19...