نتایج جستجو برای: 4c
تعداد نتایج: 3272 فیلتر نتایج به سال:
The use of 3C-based methods has revealed the importance of the 3D organization of the chromatin for key aspects of genome biology. However, the different caveats of the variants of 3C techniques have limited their scope and the range of scientific fields that could benefit from these approaches. To address these limitations, we present 4Cin, a method to generate 3D models and derive virtual Hi-...
Objective To evaluate the effects of fiber-modified hexon-chimeric recombinant oncolytic adenovirus targeting cancer associated fibroblasts (CAFs) on the gastric CAFs and the transplantation tumor mice model of gastric carcinoma (GC). Results Compared with BJ cells and GPFs, the reproduction and infectivity of P9, P9-4C or GP adenoviruses were markedly higher in gastric CAFs. In addition, P9,...
تجزیه و تحلیل کاریوتیپ، شمارش کروموزومی در مرحله میتوز، تعیین حجم و طول کلی مجموعه کروموزوم‌ها، تخمین مقدار DNA 4C و تعیین حجم هسته در مرحله بین تقسیم برای 6 گونه آکاسیا از تیره نخود انجام شده است. شمارش کروموزومی 2n= 26 برای گونه‌های Acacia aurculiformis ، A. dealbata، A. decurrens، A. catecho، A. suma، 2n= 52 برای گونه A. mollisima برای اولین بار گزارش می‌گردد. تنوع قابل ملاحظه‌ای در مقدار ...
Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines.
Twenty trihaloacetylazulene derivatives with one atom of fluorine, chlorine, bromine or iodine was investigated for their tumor-specific cytotoxicity and apoptosis-inducing activity against three human normal cells (gingival fibroblast, HGF; pulp cell, HPC; periodontal ligament fibroblast, HPLF) and four human tumor cell lines (squamous cell carcinoma, HSC-2, HSC-3, HSC-4; promyelocytic leukemi...
Epithelial and endothelial cells expressing the primary Coxsackie virus B adenovirus (Ad) receptor (CAR) and integrin coreceptors are natural targets of human Ad infections. The fiber knob of species A, C, D, E and F Ad serotypes binds CAR by mimicking the CAR-homodimer interface, and the penton base containing arginine-glycine-aspartate (RGD) motifs binds with low affinity to alphav integrins ...
This paper presents a framework for generating, representing, and interacting with the line congruences associated with four general finite poses. These line congruences are the solution space of spatial 4C mechanisms which will guide a moving body through the four prescribed poses. Hence, the contributions of this paper are applicable to developing interactive tools for designing spatial 4C me...
Three derivatives of substituted 1,2,3-thia- or 1,2,3-selenadiazole (4a-c) were prepared and characterized by different chemical techniques. These compounds were evaluated for their antimicrobial and antitumor activities. Compounds 4a (propenoxide derivative), 4b (carbaldehyde derivative), and 4c (benzene derivative) were active against the yeast-like fungi Candida albicans. Compound 4a was act...
To gain insight into early embryo development, we used microarray technology to compare gene expression profiles in metaphase II oocytes and one- (1C), two- (2C) and four-cell (4C) embryos. Differences in spot intensities were normalised and grouped using Avadis Prophetic software platform (version 3.3; Strand Genomics, Bangalore, India) and categories were based on the PANTHER and Gene Ontolog...
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