The chemotherapeutic agent 5-Fluorouracil (5-FU) is the most commonly used drug for patients with advanced colon cancer. However, development of resistance to 5-FU is inevitable in almost all patients. The mechanism by which colon cancer develops 5-FU resistance is still unclear. One recently proposed theory is that cancer stem-like cells underlie colon cancer 5-FU resistance, but the phenotype...

The aim was to make a retrospective analysis of the results surgical treatment patients with complicated diverticular disease in combination colon cancer. We analyzed retrospectively medical data 206 who underwent for period 1998–2018. Among them, 26 still had malignant neoplasms colon. diagnoses were established using instrumental diagnostic methods (colonic contrast enema and colonoscopy) con...

The Relationship between Vitamin D Deficiency and Increased Oxidative Stress in Patients with Colon Cancer

PURPOSE Neural invasion (NI) is a histopathologic feature of colon cancer that receives little consideration. Therefore, we conducted a morphologic and functional characterization of NI in colon cancer. EXPERIMENTAL DESIGN NI was investigated in 673 patients with colon cancer. Localization and severity of NI was determined and related to patient's prognosis and survival. The neuro-affinity of...

introduction: c - reactive protein (crp) is an acute-phase plasma protein that can be used as a marker of activation of the immune system. in response to several inflammatory reactions,the concentration of crp increases and recently have been applicated as a cancer detector in some studies. we aimed to evaluate the relation between crp level and the staging and grading of gastric and colon mali...

background: metastasis and recurrence of colorectal cancer after treatment is attributed to stem cells. the aim of this study was to determine the relationship between the expression of stem cell marker cd166 in colorectal cancer by immunohistochemistry and clinicopathologic parameters.methods: from 2006 to 2012, 121 colectomy specimens of patients with colon cancer that were operated in babol ...

PURPOSE This study was implemented to investigate the associations between SNP in mature microRNA (miRNA) sequence and lung cancer prognosis and to verify the function of those SNP. EXPERIMENTAL DESIGN Eight SNPs (rs3746444T>C in hsa-mir-499, rs4919510C>G in hsa-mir-608, rs13299349G>A in hsa-mir-3152, rs12220909G>C in hsa-mir-4293, rs2168518G>A in hsa-mir-4513, rs8078913T>C in hsa-mir-4520a, ...

Colon cancer is a common disease that can be sporadic, familial, or inherited. Recent advances have contributed to the understanding of the molecular basis of these various patterns of colon cancer. Germline genetic mutations are the basis of inherited colon cancer syndromes; an accumulation of somatic mutations in a cell is the basis of sporadic colon cancer; and, in Ashkenazi Jewish persons, ...

Curcumin exhibits both cancer- preventive activity and growth inhibitory effects on several neoplastic cells including human colon cancer. Serotonin and its receptors have also been implicated in tumor development. This study investigated the effect of ritanserin, a selective serotonin 5HT2A receptor antagonist, alone and in combination with curcumin on colorectal cancer cell lines. Result...

BACKGROUND Colon cancer can arise from the mucosa in a colonic diverticulum. Although colon diverticulum is a common disease, few cases have been previously reported on colon cancer associated with a diverticulum. We report a rare case of sigmoid colon cancer arising in a diverticulum with involvement of the urinary bladder, which presented characteristic radiographic images. CASE PRESENTATIO...