to develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to knoevenage...

A number of substituted quinazolones are well known for their pharmacological activities like anti-inflammatory, antibacterial and analgesic etc. The present work deals with synthesis of quinazolone based thiazolidinone in order to enhance the biological properties. A Series of (2-(substituted phenyl)-4-oxothiazolidin-3-yl) -4(4-oxo-2-phenyl quinazolin-3(4H)-yl) benzamide (6a-6h) were synthesiz...

BACKGROUND The impact of global warming and associated climate changes have built up pressure to focus on the option of green chemistry over traditional one for long term sustainability of the environment. Considering the fact, for the first time, efficient HLE catalysed expeditious one-pot synthesis of highly functionalised 4-thiazolidinones has been developed. RESULTS These hybrid molecules...

Several feasible mechanisms have been proposed as sources of neuronal damage from ischemia and subsequent reperfusion. Included among these are oxidative damage caused by free radical production and lipid peroxidation and products derived from phospholipid breakdown. A series of 4-thiazolidinone compounds represented by LY178002 (5-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene-4-thiazol...