نتایج جستجو برای: 4 oxo 4h pyran
تعداد نتایج: 1313865 فیلتر نتایج به سال:
Glucose-responsive nanogels based on dextran and poly(3-acrylamidophenylboronic acid) (PAAPBA) were fabricated by a facile self-assembly assisted (SAA) strategy. Further introduction of the fluorescent agent 2-[4-(3-hydroxy-4-oxo-4H-chromen-2-yl)phenoxy]ethylacrylamide (3HF-AM) allowed visualization of this glucose sensitivity, thus ensuring their potential use as glucose sensors.
Carboxhydrazides 3 were synthesized by reaction of substituted furo[3,2-b]pyrrole-5-carboxhydrazides 1 with 4-oxo-4H-chromene-2-carboxaldehyde 2 in the presence of 3-methyl-benzenesulfonic acid in ethanol. Carboxhydrazides 3 were used as ligands for synthesis of Cu, Co, and Ni complexes 4.
Inactivation of the switch/sucrose nonfermentable complex component SMARCB1 is extremely prevalent in pediatric malignant rhabdoid tumors (MRTs) or atypical teratoid rhabdoid tumors. This alteration is hypothesized to confer oncogenic dependency on EZH2 in these cancers. We report the discovery of a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity, ...
A series of S-glycosyl and S-alkyl derivatives of 4-amino-3-mercapto-6-(2-(2-thienyl)vinyl)-1,2,4-triazin-5(4H)-one (1) were synthesized using different halo compounds such as preacetylated sugar bromide, 4-bromobutylacetate, 2-acetoxyethoxy-methyl bromide, 3-chloropropanol, 1,3-dichloro-2-propanol, epichlorohydrin, allyl bromide, propargyl bromide, phthalic and succinic acids in POCl3. The str...
We designed a ceria-vanadia/silica (Ce-V/SiO2) heterogeneous catalyst and used it for the green and efficient synthesis of 2-amino-3-cyano-4H-pyran derivatives. The green reaction was a multicomponent one-pot condensation of 5,5-dimethylcyclohexane-1,3-dione, aromatic aldehyde, and malononitrile in an eco-compatible solvent (ethanol). The catalyst was synthesized and fully characterized by powd...
The 4H-pyran ring of the title compound, C(17)H(16)N(2)O(2), is nearly planar [maximum deviation = 0.077 (2) Å] and the cyclo-hexene ring adopts a flattened chair conformation [puckering parameters: Q(T) = 0.435 (2) Å, θ = 122.0 (3)° and ϕ = 53.5 (3)°]. The 4H-pyran ring is almost perpendicular to the benzene ring [dihedral angle = 87.23 (8)°] and is almost coplanar with the mean plane of the c...
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