نتایج جستجو برای: 4 hydroxy 2 nonenal

تعداد نتایج: 3126698  

Journal: :Molecular bioSystems 2013
Qi Liu Jody Ullery Jing Zhu Daniel C Liebler Lawrence J Marnett Bing Zhang

Reactive electrophiles produced during oxidative stress, such as 4-hydroxynonenal (HNE), are increasingly recognized as contributing factors in a variety of degenerative and inflammatory diseases. Here we used the RNA-seq technology to characterize transcriptome responses in RKO cells induced by HNE at subcytotoxic and cytotoxic doses. RNA-seq analysis rediscovered most of the differentially ex...

2001
Neven Zarkovic Tomislav Zarkovic

Neutrophil polymorphonuclear granulocytes, the largest population of leukocytes, act as phagocytes within the humanimmune system. They posses a high potential to destroy tumor cells by oxidative and non-oxidative mechanisms. Thesemechanisms, with special emphasis on the myeloperoxidase-hydrogen peroxide-halide system, are described in thiscontribution as well as the defense stra...

2015
Rudolf J. Schaur Werner Siems Nikolaus Bresgen Peter M. Eckl Michael Breitenbach Peter Eckl

This review on recent research advances of the lipid peroxidation product 4-hydroxy-nonenal (HNE) has four major topics: I. the formation of HNE in various organs and tissues, II. the diverse biochemical reactions with Michael adduct formation as the most prominent one, III. the endogenous targets of HNE, primarily peptides and proteins (here the mechanisms of covalent adduct formation are desc...

Journal: :Stroke 2011
Qin Hu Qingyi Ma Yan Zhan Zhaohui He Jiping Tang Changman Zhou John Zhang

BACKGROUND AND PURPOSE Because the potential neuroprotective effect of isoflurane is controversial, we attempted to study whether isoflurane after treatment provides neuroprotection in a rat model of hyperglycemia-induced ischemic hemorrhagic transformation. METHODS Rats received an injection of 50% dextrose (6 mL/kg intraperitoneally) and had a middle cerebral artery occlusion 30 minutes lat...

2011
Oscar Gonzalez-Perez

HNE 4-Hydroxy-2-nonenal 5-HT 5-Hydroxytryptamine ATPase Adenosine triphosphatase ALA Alpha-lipoic acid DNA Deoxyribonucleic acid GABA Gamma-amino butyric acid GPX Glutathione peroxidase GAP43 Growth-associated protein 43 NAD+ Nicotinamide adenine dinucleotide oxidized NADP+ Nicotinamide adenine dinucleotide phosphate oxidized NADHP Nicotinamide adenine dinucleotide phosphate reduced NADH Nicoti...

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